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ITCH regulates oxidative stress induced by high glucose through thioredoxin interacting protein in cultured human lens epithelial cells
Thioredoxin (Trx) is an important protein that controls oxidative damage in almost all eukaryotic cells. Trx interaction protein (Txnip) has been reported to negatively regulate the bioavailability of Trx and inhibit its biological function. The E3 ubiquitin ligase ITCH can specifically degrade Txni...
Autores principales: | Jiang, Lingfeng, Zhou, Wenkai, Lu, Bo, Yan, Qichang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533507/ https://www.ncbi.nlm.nih.gov/pubmed/32901881 http://dx.doi.org/10.3892/mmr.2020.11499 |
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