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Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response

The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial ef...

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Detalles Bibliográficos
Autores principales: Mercer, Derry K., O'Neil, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533533/
https://www.ncbi.nlm.nih.gov/pubmed/33072081
http://dx.doi.org/10.3389/fimmu.2020.02177
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author Mercer, Derry K.
O'Neil, Deborah A.
author_facet Mercer, Derry K.
O'Neil, Deborah A.
author_sort Mercer, Derry K.
collection PubMed
description The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well as immune cell therapies. The focus of this manuscript will be a non-exhaustive review of antifungal compounds in preclinical and clinical development that are based on the principles of immunology and the authors acknowledge the incredible amount of in vitro and in vivo work that has been conducted to develop such therapeutic candidates.
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spelling pubmed-75335332020-10-16 Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response Mercer, Derry K. O'Neil, Deborah A. Front Immunol Immunology The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well as immune cell therapies. The focus of this manuscript will be a non-exhaustive review of antifungal compounds in preclinical and clinical development that are based on the principles of immunology and the authors acknowledge the incredible amount of in vitro and in vivo work that has been conducted to develop such therapeutic candidates. Frontiers Media S.A. 2020-09-17 /pmc/articles/PMC7533533/ /pubmed/33072081 http://dx.doi.org/10.3389/fimmu.2020.02177 Text en Copyright © 2020 Mercer and O'Neil. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mercer, Derry K.
O'Neil, Deborah A.
Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title_full Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title_fullStr Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title_full_unstemmed Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title_short Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
title_sort innate inspiration: antifungal peptides and other immunotherapeutics from the host immune response
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533533/
https://www.ncbi.nlm.nih.gov/pubmed/33072081
http://dx.doi.org/10.3389/fimmu.2020.02177
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