SARS-CoV-2 Virion Stabilization by Zn Binding

Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we...

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Detalles Bibliográficos
Autores principales: Morante, Silvia, La Penna, Giovanni, Rossi, Giancarlo, Stellato, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533540/
https://www.ncbi.nlm.nih.gov/pubmed/33195401
http://dx.doi.org/10.3389/fmolb.2020.00222
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author Morante, Silvia
La Penna, Giovanni
Rossi, Giancarlo
Stellato, Francesco
author_facet Morante, Silvia
La Penna, Giovanni
Rossi, Giancarlo
Stellato, Francesco
author_sort Morante, Silvia
collection PubMed
description Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
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spelling pubmed-75335402020-11-12 SARS-CoV-2 Virion Stabilization by Zn Binding Morante, Silvia La Penna, Giovanni Rossi, Giancarlo Stellato, Francesco Front Mol Biosci Molecular Biosciences Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation. Frontiers Media S.A. 2020-09-17 /pmc/articles/PMC7533540/ /pubmed/33195401 http://dx.doi.org/10.3389/fmolb.2020.00222 Text en Copyright © 2020 Morante, La Penna, Rossi and Stellato. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Morante, Silvia
La Penna, Giovanni
Rossi, Giancarlo
Stellato, Francesco
SARS-CoV-2 Virion Stabilization by Zn Binding
title SARS-CoV-2 Virion Stabilization by Zn Binding
title_full SARS-CoV-2 Virion Stabilization by Zn Binding
title_fullStr SARS-CoV-2 Virion Stabilization by Zn Binding
title_full_unstemmed SARS-CoV-2 Virion Stabilization by Zn Binding
title_short SARS-CoV-2 Virion Stabilization by Zn Binding
title_sort sars-cov-2 virion stabilization by zn binding
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533540/
https://www.ncbi.nlm.nih.gov/pubmed/33195401
http://dx.doi.org/10.3389/fmolb.2020.00222
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