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Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity

Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian rhythms are controlled by molecular clocks in the brain and periphery, which is driven by clock genes. The circadian rhythm is propagated from the brain to the periphery by nerves and hormones. Glucocorticoids (GC...

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Autores principales: Shimba, Akihiro, Ikuta, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533542/
https://www.ncbi.nlm.nih.gov/pubmed/33072078
http://dx.doi.org/10.3389/fimmu.2020.02143
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author Shimba, Akihiro
Ikuta, Koichi
author_facet Shimba, Akihiro
Ikuta, Koichi
author_sort Shimba, Akihiro
collection PubMed
description Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian rhythms are controlled by molecular clocks in the brain and periphery, which is driven by clock genes. The circadian rhythm is propagated from the brain to the periphery by nerves and hormones. Glucocorticoids (GCs) are a class of steroid hormones produced by the adrenal cortex under the control of the circadian rhythm and the stress. GCs have both positive and negative effects on the immune system. Indeed, they are well known for their strong anti-inflammatory and immunosuppressive effects. Endogenous GCs inhibit the expression of inflammatory cytokines and chemokines at the active phase of mice, regulating the circadian rhythm of tissue inflammation. In addition, GCs induce the rhythmic expression of IL-7R and CXCR4 on T cells, which supports T cell maintenance and homing to lymphoid tissues. Clock genes and adrenergic neural activity control the T cell migration and immune response. Taken together, circadian factors shape the diurnal oscillation of innate and adaptive immunity. Among them, GCs participate in the circadian rhythm of innate and adaptive immunity by positive and negative effects.
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spelling pubmed-75335422020-10-15 Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity Shimba, Akihiro Ikuta, Koichi Front Immunol Immunology Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian rhythms are controlled by molecular clocks in the brain and periphery, which is driven by clock genes. The circadian rhythm is propagated from the brain to the periphery by nerves and hormones. Glucocorticoids (GCs) are a class of steroid hormones produced by the adrenal cortex under the control of the circadian rhythm and the stress. GCs have both positive and negative effects on the immune system. Indeed, they are well known for their strong anti-inflammatory and immunosuppressive effects. Endogenous GCs inhibit the expression of inflammatory cytokines and chemokines at the active phase of mice, regulating the circadian rhythm of tissue inflammation. In addition, GCs induce the rhythmic expression of IL-7R and CXCR4 on T cells, which supports T cell maintenance and homing to lymphoid tissues. Clock genes and adrenergic neural activity control the T cell migration and immune response. Taken together, circadian factors shape the diurnal oscillation of innate and adaptive immunity. Among them, GCs participate in the circadian rhythm of innate and adaptive immunity by positive and negative effects. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7533542/ /pubmed/33072078 http://dx.doi.org/10.3389/fimmu.2020.02143 Text en Copyright © 2020 Shimba and Ikuta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shimba, Akihiro
Ikuta, Koichi
Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title_full Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title_fullStr Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title_full_unstemmed Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title_short Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
title_sort glucocorticoids regulate circadian rhythm of innate and adaptive immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533542/
https://www.ncbi.nlm.nih.gov/pubmed/33072078
http://dx.doi.org/10.3389/fimmu.2020.02143
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