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Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey

BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory dat...

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Autores principales: Karahan, Serkan, Katkat, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Paris 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533663/
https://www.ncbi.nlm.nih.gov/pubmed/33491033
http://dx.doi.org/10.1007/s12603-020-1479-0
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author Karahan, Serkan
Katkat, F.
author_facet Karahan, Serkan
Katkat, F.
author_sort Karahan, Serkan
collection PubMed
description BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality. RESULTS: Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality. CONCLUSION: Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.
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spelling pubmed-75336632020-10-05 Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey Karahan, Serkan Katkat, F. J Nutr Health Aging Article BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality. RESULTS: Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality. CONCLUSION: Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients. Springer Paris 2020-10-05 2021 /pmc/articles/PMC7533663/ /pubmed/33491033 http://dx.doi.org/10.1007/s12603-020-1479-0 Text en © Serdi and Springer-Verlag International SAS, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Karahan, Serkan
Katkat, F.
Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title_full Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title_fullStr Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title_full_unstemmed Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title_short Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
title_sort impact of serum 25(oh) vitamin d level on mortality in patients with covid-19 in turkey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533663/
https://www.ncbi.nlm.nih.gov/pubmed/33491033
http://dx.doi.org/10.1007/s12603-020-1479-0
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