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Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey
BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory dat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Paris
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533663/ https://www.ncbi.nlm.nih.gov/pubmed/33491033 http://dx.doi.org/10.1007/s12603-020-1479-0 |
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author | Karahan, Serkan Katkat, F. |
author_facet | Karahan, Serkan Katkat, F. |
author_sort | Karahan, Serkan |
collection | PubMed |
description | BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality. RESULTS: Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality. CONCLUSION: Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients. |
format | Online Article Text |
id | pubmed-7533663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Paris |
record_format | MEDLINE/PubMed |
spelling | pubmed-75336632020-10-05 Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey Karahan, Serkan Katkat, F. J Nutr Health Aging Article BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21–29 ng/mL), and deficiency (<20 ng/ mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality. RESULTS: Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 ± 15.3 (range 24–90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 ± 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 ± 6.2 vs. 26.3 ± 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality. CONCLUSION: Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients. Springer Paris 2020-10-05 2021 /pmc/articles/PMC7533663/ /pubmed/33491033 http://dx.doi.org/10.1007/s12603-020-1479-0 Text en © Serdi and Springer-Verlag International SAS, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Karahan, Serkan Katkat, F. Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title_full | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title_fullStr | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title_full_unstemmed | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title_short | Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey |
title_sort | impact of serum 25(oh) vitamin d level on mortality in patients with covid-19 in turkey |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533663/ https://www.ncbi.nlm.nih.gov/pubmed/33491033 http://dx.doi.org/10.1007/s12603-020-1479-0 |
work_keys_str_mv | AT karahanserkan impactofserum25ohvitamindlevelonmortalityinpatientswithcovid19inturkey AT katkatf impactofserum25ohvitamindlevelonmortalityinpatientswithcovid19inturkey |