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Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients

PURPOSE: The aqueous humor (AH) liquid biopsy enables in vivo evaluation of tumor-derived cell-free DNA (cfDNA) from retinoblastoma (RB) eyes. Herein, we test our hypothesis that longitudinal dynamics of AH cfDNA—including tumor fraction (TFx) and somatic copy number alteration (SCNA) amplitude—corr...

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Detalles Bibliográficos
Autores principales:	Polski, Ashley, Xu, Liya, Prabakar, Rishvanth K., Kim, Jonathan W., Shah, Rachana, Jubran, Rima, Kuhn, Peter, Cobrinik, David, Hicks, James, Berry, Jesse L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533735/ https://www.ncbi.nlm.nih.gov/pubmed/33062393 http://dx.doi.org/10.1167/tvst.9.10.30

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