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The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis

BACKGROUND: Several studies have identified fatigue as one of the major symptoms experienced during and after cancer treatment. However, there are limited options to manage cancer related fatigue (CRF) with pharmacological interventions. Several acupuncture studies suggested that acupuncture has a p...

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Autores principales: Jang, Andrew, Brown, Chris, Lamoury, Gillian, Morgia, Marita, Boyle, Frances, Marr, Isobel, Clarke, Stephen, Back, Michael, Oh, Byeongsang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533944/
https://www.ncbi.nlm.nih.gov/pubmed/32996339
http://dx.doi.org/10.1177/1534735420949679
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author Jang, Andrew
Brown, Chris
Lamoury, Gillian
Morgia, Marita
Boyle, Frances
Marr, Isobel
Clarke, Stephen
Back, Michael
Oh, Byeongsang
author_facet Jang, Andrew
Brown, Chris
Lamoury, Gillian
Morgia, Marita
Boyle, Frances
Marr, Isobel
Clarke, Stephen
Back, Michael
Oh, Byeongsang
author_sort Jang, Andrew
collection PubMed
description BACKGROUND: Several studies have identified fatigue as one of the major symptoms experienced during and after cancer treatment. However, there are limited options to manage cancer related fatigue (CRF) with pharmacological interventions. Several acupuncture studies suggested that acupuncture has a positive impact on CRF. This review aims to assess the evidence of acupuncture for the treatment of CRF. METHOD: Electronic database searches were conducted on 4 English databases (Medline, PubMed, Embase, and ScienceDirect). Search keywords were; “acupuncture” and “cancer,” or “cancer related fatigue.” Studies published as full text randomized controlled trials (RCTs) in English were included. Estimates of change in fatigue cores were pooled using a random effects meta-analysis where randomized comparisons were available for true acupuncture versus sham acupuncture and true acupuncture versus usual care. The quality of original papers were assessed using the Cochrane Collaboration’s tool for assessing risk of bias (ROB). RESULTS: Nine RCTs were selected for review with a total of 809 participants and a range of 13 to 302 participants within the studies. Six RCTs reported significant improvement of CRF for the acupuncture intervention compared to the control groups. Pooled estimates suggest Brief Fatigue Inventory scores are 0.93 points lower 95% CI (−1.65, −0.20) in true acupuncture versus sham acupuncture and 2.12 points lower 95% C (−3.21, −1.04) in true acupuncture versus usual care. Six studies had low risk of bias (ROB) and 3 studies had a moderate ROB predominantly in blinding of participants, blinding of assessors and incomplete data outcomes. Among the 9 RCTs, 2 studies have reported the occurrence of minor adverse effects (spot bleeding and bruising) related to acupuncture treatment. No serious adverse reactions related to acupuncture were reported. CONCLUSION: The current literature review suggests that acupuncture has therapeutic potential in management of CRF for cancer survivors. Promotion of acupuncture in cancer care to manage CRF may improve the quality of life of cancer survivors.
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spelling pubmed-75339442020-10-14 The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis Jang, Andrew Brown, Chris Lamoury, Gillian Morgia, Marita Boyle, Frances Marr, Isobel Clarke, Stephen Back, Michael Oh, Byeongsang Integr Cancer Ther Review Article BACKGROUND: Several studies have identified fatigue as one of the major symptoms experienced during and after cancer treatment. However, there are limited options to manage cancer related fatigue (CRF) with pharmacological interventions. Several acupuncture studies suggested that acupuncture has a positive impact on CRF. This review aims to assess the evidence of acupuncture for the treatment of CRF. METHOD: Electronic database searches were conducted on 4 English databases (Medline, PubMed, Embase, and ScienceDirect). Search keywords were; “acupuncture” and “cancer,” or “cancer related fatigue.” Studies published as full text randomized controlled trials (RCTs) in English were included. Estimates of change in fatigue cores were pooled using a random effects meta-analysis where randomized comparisons were available for true acupuncture versus sham acupuncture and true acupuncture versus usual care. The quality of original papers were assessed using the Cochrane Collaboration’s tool for assessing risk of bias (ROB). RESULTS: Nine RCTs were selected for review with a total of 809 participants and a range of 13 to 302 participants within the studies. Six RCTs reported significant improvement of CRF for the acupuncture intervention compared to the control groups. Pooled estimates suggest Brief Fatigue Inventory scores are 0.93 points lower 95% CI (−1.65, −0.20) in true acupuncture versus sham acupuncture and 2.12 points lower 95% C (−3.21, −1.04) in true acupuncture versus usual care. Six studies had low risk of bias (ROB) and 3 studies had a moderate ROB predominantly in blinding of participants, blinding of assessors and incomplete data outcomes. Among the 9 RCTs, 2 studies have reported the occurrence of minor adverse effects (spot bleeding and bruising) related to acupuncture treatment. No serious adverse reactions related to acupuncture were reported. CONCLUSION: The current literature review suggests that acupuncture has therapeutic potential in management of CRF for cancer survivors. Promotion of acupuncture in cancer care to manage CRF may improve the quality of life of cancer survivors. SAGE Publications 2020-09-30 /pmc/articles/PMC7533944/ /pubmed/32996339 http://dx.doi.org/10.1177/1534735420949679 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Jang, Andrew
Brown, Chris
Lamoury, Gillian
Morgia, Marita
Boyle, Frances
Marr, Isobel
Clarke, Stephen
Back, Michael
Oh, Byeongsang
The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title_full The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title_fullStr The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title_full_unstemmed The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title_short The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
title_sort effects of acupuncture on cancer-related fatigue: updated systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533944/
https://www.ncbi.nlm.nih.gov/pubmed/32996339
http://dx.doi.org/10.1177/1534735420949679
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