Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification

There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position...

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Detalles Bibliográficos
Autores principales: Parker, Richard A, Weir, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534018/
https://www.ncbi.nlm.nih.gov/pubmed/32666813
http://dx.doi.org/10.1177/1740774520941419
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author Parker, Richard A
Weir, Christopher J
author_facet Parker, Richard A
Weir, Christopher J
author_sort Parker, Richard A
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description There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
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spelling pubmed-75340182020-10-14 Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification Parker, Richard A Weir, Christopher J Clin Trials Perspective There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments. SAGE Publications 2020-07-15 2020-10 /pmc/articles/PMC7534018/ /pubmed/32666813 http://dx.doi.org/10.1177/1740774520941419 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Perspective
Parker, Richard A
Weir, Christopher J
Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title_full Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title_fullStr Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title_full_unstemmed Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title_short Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification
title_sort non-adjustment for multiple testing in multi-arm trials of distinct treatments: rationale and justification
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534018/
https://www.ncbi.nlm.nih.gov/pubmed/32666813
http://dx.doi.org/10.1177/1740774520941419
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