Cargando…

HIV-1 resists MxB inhibition of viral Rev protein

The interferon-inducible myxovirus resistance B (MxB) protein has been reported to inhibit HIV-1 and herpesviruses by blocking the nuclear import of viral DNA. Here, we report a new antiviral mechanism in which MxB restricts the nuclear import of HIV-1 regulatory protein Rev, and as a result, dimini...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhen, Chai, Keli, Liu, Qian, Yi, Dong-Rong, Pan, Qinghua, Huang, Yu, Tan, Juan, Qiao, Wentao, Guo, Fei, Cen, Shan, Liang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534208/
https://www.ncbi.nlm.nih.gov/pubmed/32873191
http://dx.doi.org/10.1080/22221751.2020.1818633
Descripción
Sumario:The interferon-inducible myxovirus resistance B (MxB) protein has been reported to inhibit HIV-1 and herpesviruses by blocking the nuclear import of viral DNA. Here, we report a new antiviral mechanism in which MxB restricts the nuclear import of HIV-1 regulatory protein Rev, and as a result, diminishes Rev-dependent expression of HIV-1 Gag protein. Specifically, MxB disrupts the interaction of Rev with the nuclear transport receptor, transportin 1 (TNPO1). Supporting this, the TNPO1-independent Rev variants become less restricted by MxB. In addition, HIV-1 can overcome this inhibition by MxB through increasing the expression of multiply spliced viral RNA and hence Rev protein. Therefore, MxB exerts its anti-HIV-1 function through interfering with the nuclear import of both viral DNA and viral Rev protein.