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Methyl 5-chloro-4-hydroxy-2,2-dioxo-1H-2λ(6),1-benzothiazine-3-carboxylate: structure and Hirshfeld surface analysis
The title compound, C(10)H(8)ClNO(5)S, which has potential analgesic activity, crystallizes in space group P2(1)/n. The benzothiazine ring system adopts an intermediate form between sofa and twist-boat conformations. The coplanarity of the ester substituent to the bicyclic fragment is stabilized...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534242/ https://www.ncbi.nlm.nih.gov/pubmed/33117584 http://dx.doi.org/10.1107/S2056989020012566 |
Sumario: | The title compound, C(10)H(8)ClNO(5)S, which has potential analgesic activity, crystallizes in space group P2(1)/n. The benzothiazine ring system adopts an intermediate form between sofa and twist-boat conformations. The coplanarity of the ester substituent to the bicyclic fragment is stabilized by an O—H⋯O intramolecular hydrogen bond. In the crystal, hydrogen bonds of type N—H⋯O(SO(2)) link the molecules into zigzag chains extending along the b-axis direction. Neighbouring chains are linked by both O—H⋯Cl and C—H⋯Cl interactions. A Hirshfeld surface analysis was used to compare different types of intermolecular interactions, giving contributions of O⋯H/H⋯O = 42.0%, C⋯H/H⋯C = 17.3%, Cl⋯H/H⋯Cl = 14.2%, H⋯H = 11.1%. |
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