SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovi...

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Detalles Bibliográficos
Autores principales: Wang, Pengfei, Liu, Lihong, Nair, Manoj S., Yin, Michael T., Luo, Yang, Wang, Qian, Yuan, Ting, Mori, Kanako, Solis, Axel Guzman, Yamashita, Masahiro, Garg, Ankur, Purpura, Lawrence J., Laracy, Justin C., Yu, Jian, Joshua-Tor, Leemor, Sodroski, Joseph, Huang, Yaoxing, Ho, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534308/
https://www.ncbi.nlm.nih.gov/pubmed/32930052
http://dx.doi.org/10.1080/22221751.2020.1823890
Descripción
Sumario:We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

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