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SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovi...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534308/ https://www.ncbi.nlm.nih.gov/pubmed/32930052 http://dx.doi.org/10.1080/22221751.2020.1823890 |
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| author | Wang, Pengfei Liu, Lihong Nair, Manoj S. Yin, Michael T. Luo, Yang Wang, Qian Yuan, Ting Mori, Kanako Solis, Axel Guzman Yamashita, Masahiro Garg, Ankur Purpura, Lawrence J. Laracy, Justin C. Yu, Jian Joshua-Tor, Leemor Sodroski, Joseph Huang, Yaoxing Ho, David D. |
| author_facet | Wang, Pengfei Liu, Lihong Nair, Manoj S. Yin, Michael T. Luo, Yang Wang, Qian Yuan, Ting Mori, Kanako Solis, Axel Guzman Yamashita, Masahiro Garg, Ankur Purpura, Lawrence J. Laracy, Justin C. Yu, Jian Joshua-Tor, Leemor Sodroski, Joseph Huang, Yaoxing Ho, David D. |
| author_sort | Wang, Pengfei |
| collection | PubMed |
| description | We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity. |
| format | Online Article Text |
| id | pubmed-7534308 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75343082020-10-14 SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease Wang, Pengfei Liu, Lihong Nair, Manoj S. Yin, Michael T. Luo, Yang Wang, Qian Yuan, Ting Mori, Kanako Solis, Axel Guzman Yamashita, Masahiro Garg, Ankur Purpura, Lawrence J. Laracy, Justin C. Yu, Jian Joshua-Tor, Leemor Sodroski, Joseph Huang, Yaoxing Ho, David D. Emerg Microbes Infect Letter We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity. Taylor & Francis 2020-09-25 /pmc/articles/PMC7534308/ /pubmed/32930052 http://dx.doi.org/10.1080/22221751.2020.1823890 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Letter Wang, Pengfei Liu, Lihong Nair, Manoj S. Yin, Michael T. Luo, Yang Wang, Qian Yuan, Ting Mori, Kanako Solis, Axel Guzman Yamashita, Masahiro Garg, Ankur Purpura, Lawrence J. Laracy, Justin C. Yu, Jian Joshua-Tor, Leemor Sodroski, Joseph Huang, Yaoxing Ho, David D. SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title | SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title_full | SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title_fullStr | SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title_full_unstemmed | SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title_short | SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease |
| title_sort | sars-cov-2 neutralizing antibody responses are more robust in patients with severe disease |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534308/ https://www.ncbi.nlm.nih.gov/pubmed/32930052 http://dx.doi.org/10.1080/22221751.2020.1823890 |
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