Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties

The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuc...

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Autores principales: Stasiłowicz, Anna, Tykarska, Ewa, Lewandowska, Kornelia, Kozak, Maciej, Miklaszewski, Andrzej, Kobus-Cisowska, Joanna, Szymanowska, Daria, Plech, Tomasz, Jenczyk, Jacek, Cielecka-Piontek, Judyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534320/
https://www.ncbi.nlm.nih.gov/pubmed/32967477
http://dx.doi.org/10.1080/14756366.2020.1801670
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author Stasiłowicz, Anna
Tykarska, Ewa
Lewandowska, Kornelia
Kozak, Maciej
Miklaszewski, Andrzej
Kobus-Cisowska, Joanna
Szymanowska, Daria
Plech, Tomasz
Jenczyk, Jacek
Cielecka-Piontek, Judyta
author_facet Stasiłowicz, Anna
Tykarska, Ewa
Lewandowska, Kornelia
Kozak, Maciej
Miklaszewski, Andrzej
Kobus-Cisowska, Joanna
Szymanowska, Daria
Plech, Tomasz
Jenczyk, Jacek
Cielecka-Piontek, Judyta
author_sort Stasiłowicz, Anna
collection PubMed
description The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
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spelling pubmed-75343202020-10-14 Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties Stasiłowicz, Anna Tykarska, Ewa Lewandowska, Kornelia Kozak, Maciej Miklaszewski, Andrzej Kobus-Cisowska, Joanna Szymanowska, Daria Plech, Tomasz Jenczyk, Jacek Cielecka-Piontek, Judyta J Enzyme Inhib Med Chem Research Paper The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase. Taylor & Francis 2020-09-23 /pmc/articles/PMC7534320/ /pubmed/32967477 http://dx.doi.org/10.1080/14756366.2020.1801670 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Stasiłowicz, Anna
Tykarska, Ewa
Lewandowska, Kornelia
Kozak, Maciej
Miklaszewski, Andrzej
Kobus-Cisowska, Joanna
Szymanowska, Daria
Plech, Tomasz
Jenczyk, Jacek
Cielecka-Piontek, Judyta
Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title_full Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title_fullStr Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title_full_unstemmed Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title_short Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
title_sort hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534320/
https://www.ncbi.nlm.nih.gov/pubmed/32967477
http://dx.doi.org/10.1080/14756366.2020.1801670
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