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Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide derivatives containing 5-phenyl-2-furan moiety...

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Detalles Bibliográficos
Autores principales:	Zhou, Tao-Shun, Wei, Bin, He, Min, Li, Ya-Sheng, Wang, Ya-Kun, Wang, Si-Jia, Chen, Jian-Wei, Zhang, Hua-Wei, Cui, Zi-Ning, Wang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534389/ https://www.ncbi.nlm.nih.gov/pubmed/32928007 http://dx.doi.org/10.1080/14756366.2020.1816998

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