Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19

The contribution of CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4(+) T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospi...

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Detalles Bibliográficos
Autores principales: Meckiff, Benjamin J., Ramírez-Suástegui, Ciro, Fajardo, Vicente, Chee, Serena J., Kusnadi, Anthony, Simon, Hayley, Eschweiler, Simon, Grifoni, Alba, Pelosi, Emanuela, Weiskopf, Daniela, Sette, Alessandro, Ay, Ferhat, Seumois, Grégory, Ottensmeier, Christian H., Vijayanand, Pandurangan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534589/
https://www.ncbi.nlm.nih.gov/pubmed/33096020
http://dx.doi.org/10.1016/j.cell.2020.10.001

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