Cargando…

Furin: A Potential Therapeutic Target for COVID-19

COVID-19 broke out in the end of December 2019 and is still spreading rapidly, which has been listed as an international concerning public health emergency. We found that the Spike protein of SARS-CoV-2 contains a furin cleavage site, which did not exist in any other betacoronavirus subtype B. Based...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Canrong, Zheng, Mengzhu, Yang, Yueying, Gu, Xiaoxia, Yang, Kaiyin, Li, Mingxue, Liu, Yang, Zhang, Qingzhe, Zhang, Peng, Wang, Yali, Wang, Qiqi, Xu, Yang, Zhou, Yirong, Zhang, Yonghui, Chen, Lixia, Li, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534598/ https://www.ncbi.nlm.nih.gov/pubmed/33043282 http://dx.doi.org/10.1016/j.isci.2020.101642

Ejemplares similares

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
por: Wu, Canrong, et al.
Publicado: (2020)

A natural DYRK1A inhibitor as a potential stimulator for β‐cell proliferation in diabetes
por: Zheng, Mengzhu, et al.
Publicado: (2021)

A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity
por: Wu, Canrong, et al.
Publicado: (2017)

Associations between genetic variations in the FURIN gene and hypertension
por: Li, Nanfang, et al.
Publicado: (2010)

Cancer/testis antigen‐Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway
por: Li, Yongfei, et al.
Publicado: (2018)

Transgenic overexpression of furin increases epileptic susceptibility
por: Yang, Yi, et al.
Publicado: (2018)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
por: Liu, Yang, et al.
Publicado: (2023)

Influence of a Coronary Artery Disease–Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior
por: Zhao, Guojun, et al.
Publicado: (2018)

Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion
por: Yang, Hui Y, et al.
Publicado: (2014)

Furin as a therapeutic target in cystic fibrosis airways disease
por: Douglas, Lisa E.J., et al.
Publicado: (2023)

Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts
por: Wang, Wenbin, et al.
Publicado: (2021)

Proprotein Convertase Furin Regulates Apoptosis and Proliferation of Granulosa Cells in the Rat Ovary
por: Yang, Xiaokui, et al.
Publicado: (2013)

Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection
por: Wang, Zeng, et al.
Publicado: (2023)

The proprotein convertase furin is required for trophoblast syncytialization
por: Zhou, Z, et al.
Publicado: (2013)

Prodomain of Furin Promotes Phospholipid Transfer Protein Proteasomal Degradation in Hepatocytes
por: Yu, Yang, et al.
Publicado: (2018)

The emerging role of furin in neurodegenerative and neuropsychiatric diseases
por: Zhang, Yi, et al.
Publicado: (2022)

The pathological and therapeutic roles of mesenchymal stem cells in preeclampsia
por: Jin, Sanshan, et al.
Publicado: (2022)

A second functional furin site in the SARS-CoV-2 spike protein
por: Zhang, Yue, et al.
Publicado: (2022)

The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
por: Liang, Zhanfeng, et al.
Publicado: (2022)

Global Diversification and Distribution of Coronaviruses With Furin Cleavage Sites
por: Liu, Xiaotong, et al.
Publicado: (2021)

FURIN Promoter Methylation Predicts the Risk of Incident Diabetes: A Prospective Analysis in the Gusu Cohort
por: He, Yan, et al.
Publicado: (2022)

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs
por: Tian, Sun, et al.
Publicado: (2011)

A novel bat coronavirus with a polybasic furin-like cleavage site
por: Zhu, Wentao, et al.
Publicado: (2023)

Engineering, and production of functionally active human Furin in N. benthamiana plant: In vivo post-translational processing of target proteins by Furin in plants
por: Mamedov, Tarlan, et al.
Publicado: (2019)

Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults
por: He, Yan, et al.
Publicado: (2022)

Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2
por: Li, Lili, et al.
Publicado: (2022)

SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases
por: Zhou, Lulin, et al.
Publicado: (2020)

PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids
por: Wu, Yanli, et al.
Publicado: (2022)

The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2
por: Thomas, Gary, et al.
Publicado: (2022)

Permethrin as a Potential Furin Inhibitor through a Novel Non-Competitive Allosteric Inhibition
por: Feng, Dongyan, et al.
Publicado: (2023)

A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway
por: LIU, BINGSHAN, et al.
Publicado: (2014)

Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers
por: Hasegawa-Minato, Junko, et al.
Publicado: (2017)

Increased FURIN expression in rheumatoid arthritis patients and its anti‐inflammatory effect
por: Cao, Rong, et al.
Publicado: (2020)

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris
por: Huang, Yide, et al.
Publicado: (2018)

Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
por: Zeng, Jiaxin, et al.
Publicado: (2021)

FURIN and placental syncytialisation: a cautionary tale
por: Morosin, Saije K., et al.
Publicado: (2021)

Furin cleavage sites naturally occur in coronaviruses
por: Wu, Yiran, et al.
Publicado: (2021)

An Overview of the Role of Furin in Type 2 Diabetes
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Significance of Furin Expression in Thyroid Neoplastic Transformation
por: Azevedo, Maria Teresa, et al.
Publicado: (2023)

Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis
por: Pang, Yichuan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bid5t3liarutpsl22si0ho7at9