Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

Cancer metastasis accounts for the major cause of cancer-related deaths. How disseminated cancer cells cope with hostile microenvironments in secondary site for full-blown metastasis is largely unknown. Here, we show that AMPK (AMP-activated protein kinase), activated in mouse metastasis models, dri...

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Detalles Bibliográficos
Autores principales: Cai, Zhen, Li, Chien-Feng, Han, Fei, Liu, Chunfang, Zhang, Anmei, Hsu, Che-Chia, Peng, Danni, Zhang, Xian, Jin, Guoxiang, Rezaeian, Abdol-Hossein, Wang, Guihua, Zhang, Weina, Pan, Bo-Syong, Wang, Chi-Yun, Wang, Yu-Hui, Wu, Shih-Ying, Yang, Shun-Chin, Hsu, Fang-Chi, D’Agostino, Ralph B., Furdui, Christina M., Kucera, Gregory L., Parks, John S., Chilton, Floyd H., Huang, Chih-Yang, Tsai, Fuu-Jen, Pasche, Boris, Watabe, Kounosuke, Lin, Hui-Kuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534735/
https://www.ncbi.nlm.nih.gov/pubmed/33022274
http://dx.doi.org/10.1016/j.molcel.2020.09.018

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