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Structure-based validation can drastically under-estimate error rate in proteome-wide cross-linking mass spectrometry studies

Thorough quality assessment of novel interactions identified by proteome-wide cross-linking mass spectrometry (XL-MS) studies is critical. Almost all current XL-MS studies have validated cross-links against known 3D structures of representative protein complexes. Here we provide theoretical and expe...

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Detalles Bibliográficos
Autores principales:	Yugandhar, Kumar, Wang, Ting-Yi, Wierbowski, Shayne D., Shayhidin, Elnur Elyar, Yu, Haiyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534832/ https://www.ncbi.nlm.nih.gov/pubmed/32994567 http://dx.doi.org/10.1038/s41592-020-0959-9

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