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Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage
Sickle cell disease (SCD) is a common hereditary hematologic disorder. SCD patients suffer from acute vaso-occlusive episodes (VOEs), chronic organ damage, and premature death, with few therapeutic options. Although severe pain is a major clinical manifestation of SCD, it remains unknown whether noc...
Autores principales: | Xu, Chunliang, Gulinello, Maria, Frenette, Paul S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534906/ https://www.ncbi.nlm.nih.gov/pubmed/33045060 http://dx.doi.org/10.1084/jem.20200065 |
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