COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as...

Descripción completa

Detalles Bibliográficos
Autores principales: Senger, Mario Roberto, Evangelista, Tereza Cristina Santos, Dantas, Rafael Ferreira, Santana, Marcos Vinicius da Silva, Gonçalves, Luiz Carlos Saramago, de Souza Neto, Lauro Ribeiro, Ferreira, Sabrina Baptista, Silva-Junior, Floriano Paes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534958/
https://www.ncbi.nlm.nih.gov/pubmed/33027420
http://dx.doi.org/10.1590/0074-02760200254
_version_ 1783590387924860928
author Senger, Mario Roberto
Evangelista, Tereza Cristina Santos
Dantas, Rafael Ferreira
Santana, Marcos Vinicius da Silva
Gonçalves, Luiz Carlos Saramago
de Souza Neto, Lauro Ribeiro
Ferreira, Sabrina Baptista
Silva-Junior, Floriano Paes
author_facet Senger, Mario Roberto
Evangelista, Tereza Cristina Santos
Dantas, Rafael Ferreira
Santana, Marcos Vinicius da Silva
Gonçalves, Luiz Carlos Saramago
de Souza Neto, Lauro Ribeiro
Ferreira, Sabrina Baptista
Silva-Junior, Floriano Paes
author_sort Senger, Mario Roberto
collection PubMed
description Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
format Online
Article
Text
id pubmed-7534958
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Instituto Oswaldo Cruz, Ministério da Saúde
record_format MEDLINE/PubMed
spelling pubmed-75349582020-10-14 COVID-19: molecular targets, drug repurposing and new avenues for drug discovery Senger, Mario Roberto Evangelista, Tereza Cristina Santos Dantas, Rafael Ferreira Santana, Marcos Vinicius da Silva Gonçalves, Luiz Carlos Saramago de Souza Neto, Lauro Ribeiro Ferreira, Sabrina Baptista Silva-Junior, Floriano Paes Mem Inst Oswaldo Cruz Review Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment. Instituto Oswaldo Cruz, Ministério da Saúde 2020-10-02 /pmc/articles/PMC7534958/ /pubmed/33027420 http://dx.doi.org/10.1590/0074-02760200254 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Review
Senger, Mario Roberto
Evangelista, Tereza Cristina Santos
Dantas, Rafael Ferreira
Santana, Marcos Vinicius da Silva
Gonçalves, Luiz Carlos Saramago
de Souza Neto, Lauro Ribeiro
Ferreira, Sabrina Baptista
Silva-Junior, Floriano Paes
COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title_full COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title_fullStr COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title_full_unstemmed COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title_short COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
title_sort covid-19: molecular targets, drug repurposing and new avenues for drug discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534958/
https://www.ncbi.nlm.nih.gov/pubmed/33027420
http://dx.doi.org/10.1590/0074-02760200254
work_keys_str_mv AT sengermarioroberto covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT evangelistaterezacristinasantos covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT dantasrafaelferreira covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT santanamarcosviniciusdasilva covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT goncalvesluizcarlossaramago covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT desouzanetolauroribeiro covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT ferreirasabrinabaptista covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery
AT silvajuniorflorianopaes covid19moleculartargetsdrugrepurposingandnewavenuesfordrugdiscovery

Ejemplares similares