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Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19
Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Medicina Tropical - SBMT
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534972/ https://www.ncbi.nlm.nih.gov/pubmed/33027418 http://dx.doi.org/10.1590/0037-8682-0477-2020 |
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author | Puccioni-Sohler, Marzia Poton, André Rodrigues Franklin, Milena da Silva, Samya Jezine Brindeiro, Rodrigo Tanuri, Amilcar |
author_facet | Puccioni-Sohler, Marzia Poton, André Rodrigues Franklin, Milena da Silva, Samya Jezine Brindeiro, Rodrigo Tanuri, Amilcar |
author_sort | Puccioni-Sohler, Marzia |
collection | PubMed |
description | Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms. |
format | Online Article Text |
id | pubmed-7534972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Medicina Tropical - SBMT |
record_format | MEDLINE/PubMed |
spelling | pubmed-75349722020-10-06 Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 Puccioni-Sohler, Marzia Poton, André Rodrigues Franklin, Milena da Silva, Samya Jezine Brindeiro, Rodrigo Tanuri, Amilcar Rev Soc Bras Med Trop Mini Review Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms. Sociedade Brasileira de Medicina Tropical - SBMT 2020-10-05 /pmc/articles/PMC7534972/ /pubmed/33027418 http://dx.doi.org/10.1590/0037-8682-0477-2020 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Mini Review Puccioni-Sohler, Marzia Poton, André Rodrigues Franklin, Milena da Silva, Samya Jezine Brindeiro, Rodrigo Tanuri, Amilcar Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title | Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_full | Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_fullStr | Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_full_unstemmed | Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_short | Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_sort | current evidence of neurological features, diagnosis, and neuropathogenesis associated with covid-19 |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534972/ https://www.ncbi.nlm.nih.gov/pubmed/33027418 http://dx.doi.org/10.1590/0037-8682-0477-2020 |
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