Cargando…

Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France

Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outco...

Descripción completa

Detalles Bibliográficos
Autores principales: Suard, Cornélie, Flori, Audrey, Paoli, Florent, Loundou, Anderson, Fouilloux, Virginie, Sigaudy, Sabine, Michel, Fabrice, Antomarchi, Julie, Moceri, Pamela, Paquis-Flucklinger, Véronique, D’Ercole, Claude, Bretelle, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535055/
https://www.ncbi.nlm.nih.gov/pubmed/33017437
http://dx.doi.org/10.1371/journal.pone.0239476
_version_ 1783590408944615424
author Suard, Cornélie
Flori, Audrey
Paoli, Florent
Loundou, Anderson
Fouilloux, Virginie
Sigaudy, Sabine
Michel, Fabrice
Antomarchi, Julie
Moceri, Pamela
Paquis-Flucklinger, Véronique
D’Ercole, Claude
Bretelle, Florence
author_facet Suard, Cornélie
Flori, Audrey
Paoli, Florent
Loundou, Anderson
Fouilloux, Virginie
Sigaudy, Sabine
Michel, Fabrice
Antomarchi, Julie
Moceri, Pamela
Paquis-Flucklinger, Véronique
D’Ercole, Claude
Bretelle, Florence
author_sort Suard, Cornélie
collection PubMed
description Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outcomes. We performed a bicentric, retrospective observational study in the southern region over 4 years was conducted between 1 January 2014 and 31 December 2017. All foetuses and children under one year of age with CHD monitored in the UTHs (University Teaching Hospitals) in Marseille and Nice were included. CHD cases were divided into 3 groups: group 1, those with no possible options for anatomical repair; group 2, those with anatomical repair possibilities but that may require neonatal cardiologic management; and group 3, those with anatomical repair possibilities that do not require an emergency neonatal procedure. Among the 249070 deliveries during the study period, 677 CHD cases were included in the study. The overall prenatal screening rate was 71.5%. The screening rates were 97.8%, 63.6%, and 65.9% for groups 1, 2 and 3, respectively. Among group 2 CHD cases, 80% of the transpositions of the great arteries, 56% of the aortic coarctations, and 20% of the total anomalous pulmonary venous returns were detected during the prenatal period. A genetic anomaly was found in 16% of CHD cases. The overall mortality rate was 11.3% with a higher death rate in cases of prenatal screening (17.2% versus 2.1%; p < 0.001). However, when focusing only on children who died of CHD, prenatal screening did not create an impact (56.6% versus 100%, p = 0,140). Our data showed that the prenatal screening rate of CHD appears satisfactory in Southern France. Nevertheless, it could be improved for some CHD. This study did not find any benefit in terms of mortality from prenatal screening for CHD.
format Online
Article
Text
id pubmed-7535055
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-75350552020-10-15 Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France Suard, Cornélie Flori, Audrey Paoli, Florent Loundou, Anderson Fouilloux, Virginie Sigaudy, Sabine Michel, Fabrice Antomarchi, Julie Moceri, Pamela Paquis-Flucklinger, Véronique D’Ercole, Claude Bretelle, Florence PLoS One Research Article Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outcomes. We performed a bicentric, retrospective observational study in the southern region over 4 years was conducted between 1 January 2014 and 31 December 2017. All foetuses and children under one year of age with CHD monitored in the UTHs (University Teaching Hospitals) in Marseille and Nice were included. CHD cases were divided into 3 groups: group 1, those with no possible options for anatomical repair; group 2, those with anatomical repair possibilities but that may require neonatal cardiologic management; and group 3, those with anatomical repair possibilities that do not require an emergency neonatal procedure. Among the 249070 deliveries during the study period, 677 CHD cases were included in the study. The overall prenatal screening rate was 71.5%. The screening rates were 97.8%, 63.6%, and 65.9% for groups 1, 2 and 3, respectively. Among group 2 CHD cases, 80% of the transpositions of the great arteries, 56% of the aortic coarctations, and 20% of the total anomalous pulmonary venous returns were detected during the prenatal period. A genetic anomaly was found in 16% of CHD cases. The overall mortality rate was 11.3% with a higher death rate in cases of prenatal screening (17.2% versus 2.1%; p < 0.001). However, when focusing only on children who died of CHD, prenatal screening did not create an impact (56.6% versus 100%, p = 0,140). Our data showed that the prenatal screening rate of CHD appears satisfactory in Southern France. Nevertheless, it could be improved for some CHD. This study did not find any benefit in terms of mortality from prenatal screening for CHD. Public Library of Science 2020-10-05 /pmc/articles/PMC7535055/ /pubmed/33017437 http://dx.doi.org/10.1371/journal.pone.0239476 Text en © 2020 Suard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Suard, Cornélie
Flori, Audrey
Paoli, Florent
Loundou, Anderson
Fouilloux, Virginie
Sigaudy, Sabine
Michel, Fabrice
Antomarchi, Julie
Moceri, Pamela
Paquis-Flucklinger, Véronique
D’Ercole, Claude
Bretelle, Florence
Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title_full Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title_fullStr Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title_full_unstemmed Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title_short Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
title_sort accuracy of prenatal screening for congenital heart disease in population: a retrospective study in southern france
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535055/
https://www.ncbi.nlm.nih.gov/pubmed/33017437
http://dx.doi.org/10.1371/journal.pone.0239476
work_keys_str_mv AT suardcornelie accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT floriaudrey accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT paoliflorent accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT loundouanderson accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT fouillouxvirginie accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT sigaudysabine accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT michelfabrice accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT antomarchijulie accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT moceripamela accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT paquisflucklingerveronique accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT dercoleclaude accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance
AT bretelleflorence accuracyofprenatalscreeningforcongenitalheartdiseaseinpopulationaretrospectivestudyinsouthernfrance