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Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France
Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outco...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535055/ https://www.ncbi.nlm.nih.gov/pubmed/33017437 http://dx.doi.org/10.1371/journal.pone.0239476 |
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author | Suard, Cornélie Flori, Audrey Paoli, Florent Loundou, Anderson Fouilloux, Virginie Sigaudy, Sabine Michel, Fabrice Antomarchi, Julie Moceri, Pamela Paquis-Flucklinger, Véronique D’Ercole, Claude Bretelle, Florence |
author_facet | Suard, Cornélie Flori, Audrey Paoli, Florent Loundou, Anderson Fouilloux, Virginie Sigaudy, Sabine Michel, Fabrice Antomarchi, Julie Moceri, Pamela Paquis-Flucklinger, Véronique D’Ercole, Claude Bretelle, Florence |
author_sort | Suard, Cornélie |
collection | PubMed |
description | Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outcomes. We performed a bicentric, retrospective observational study in the southern region over 4 years was conducted between 1 January 2014 and 31 December 2017. All foetuses and children under one year of age with CHD monitored in the UTHs (University Teaching Hospitals) in Marseille and Nice were included. CHD cases were divided into 3 groups: group 1, those with no possible options for anatomical repair; group 2, those with anatomical repair possibilities but that may require neonatal cardiologic management; and group 3, those with anatomical repair possibilities that do not require an emergency neonatal procedure. Among the 249070 deliveries during the study period, 677 CHD cases were included in the study. The overall prenatal screening rate was 71.5%. The screening rates were 97.8%, 63.6%, and 65.9% for groups 1, 2 and 3, respectively. Among group 2 CHD cases, 80% of the transpositions of the great arteries, 56% of the aortic coarctations, and 20% of the total anomalous pulmonary venous returns were detected during the prenatal period. A genetic anomaly was found in 16% of CHD cases. The overall mortality rate was 11.3% with a higher death rate in cases of prenatal screening (17.2% versus 2.1%; p < 0.001). However, when focusing only on children who died of CHD, prenatal screening did not create an impact (56.6% versus 100%, p = 0,140). Our data showed that the prenatal screening rate of CHD appears satisfactory in Southern France. Nevertheless, it could be improved for some CHD. This study did not find any benefit in terms of mortality from prenatal screening for CHD. |
format | Online Article Text |
id | pubmed-7535055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75350552020-10-15 Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France Suard, Cornélie Flori, Audrey Paoli, Florent Loundou, Anderson Fouilloux, Virginie Sigaudy, Sabine Michel, Fabrice Antomarchi, Julie Moceri, Pamela Paquis-Flucklinger, Véronique D’Ercole, Claude Bretelle, Florence PLoS One Research Article Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outcomes. We performed a bicentric, retrospective observational study in the southern region over 4 years was conducted between 1 January 2014 and 31 December 2017. All foetuses and children under one year of age with CHD monitored in the UTHs (University Teaching Hospitals) in Marseille and Nice were included. CHD cases were divided into 3 groups: group 1, those with no possible options for anatomical repair; group 2, those with anatomical repair possibilities but that may require neonatal cardiologic management; and group 3, those with anatomical repair possibilities that do not require an emergency neonatal procedure. Among the 249070 deliveries during the study period, 677 CHD cases were included in the study. The overall prenatal screening rate was 71.5%. The screening rates were 97.8%, 63.6%, and 65.9% for groups 1, 2 and 3, respectively. Among group 2 CHD cases, 80% of the transpositions of the great arteries, 56% of the aortic coarctations, and 20% of the total anomalous pulmonary venous returns were detected during the prenatal period. A genetic anomaly was found in 16% of CHD cases. The overall mortality rate was 11.3% with a higher death rate in cases of prenatal screening (17.2% versus 2.1%; p < 0.001). However, when focusing only on children who died of CHD, prenatal screening did not create an impact (56.6% versus 100%, p = 0,140). Our data showed that the prenatal screening rate of CHD appears satisfactory in Southern France. Nevertheless, it could be improved for some CHD. This study did not find any benefit in terms of mortality from prenatal screening for CHD. Public Library of Science 2020-10-05 /pmc/articles/PMC7535055/ /pubmed/33017437 http://dx.doi.org/10.1371/journal.pone.0239476 Text en © 2020 Suard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Suard, Cornélie Flori, Audrey Paoli, Florent Loundou, Anderson Fouilloux, Virginie Sigaudy, Sabine Michel, Fabrice Antomarchi, Julie Moceri, Pamela Paquis-Flucklinger, Véronique D’Ercole, Claude Bretelle, Florence Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title | Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title_full | Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title_fullStr | Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title_full_unstemmed | Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title_short | Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France |
title_sort | accuracy of prenatal screening for congenital heart disease in population: a retrospective study in southern france |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535055/ https://www.ncbi.nlm.nih.gov/pubmed/33017437 http://dx.doi.org/10.1371/journal.pone.0239476 |
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