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Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age

BACKGROUND: The 2005–06 chikungunya virus (CHIKV) outbreak in La Réunion suggested that mothers could transmit CHIKV to their neonates while viremic during the intrapartum period, and more than half of the infected neonates showed impaired neurodevelopment at two years of age. However, data sparsity...

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Autores principales: Waechter, Randall, Ingraham, Erinique, Evans, Roberta, Cudjoe, Nikita, Krystosik, Amy, Isaac, Rashida, Watts, Ashlee, Noël, Trevor, Landon, Barbara, Fernandes, Michelle, Mapp-Alexander, Veronica, Suresh, Priyanka, Mitchell, George, Macpherson, Calum, Gérardin, Patrick, LaBeaud, A. Desiree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535067/
https://www.ncbi.nlm.nih.gov/pubmed/33017393
http://dx.doi.org/10.1371/journal.pntd.0008546
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author Waechter, Randall
Ingraham, Erinique
Evans, Roberta
Cudjoe, Nikita
Krystosik, Amy
Isaac, Rashida
Watts, Ashlee
Noël, Trevor
Landon, Barbara
Fernandes, Michelle
Mapp-Alexander, Veronica
Suresh, Priyanka
Mitchell, George
Macpherson, Calum
Gérardin, Patrick
LaBeaud, A. Desiree
author_facet Waechter, Randall
Ingraham, Erinique
Evans, Roberta
Cudjoe, Nikita
Krystosik, Amy
Isaac, Rashida
Watts, Ashlee
Noël, Trevor
Landon, Barbara
Fernandes, Michelle
Mapp-Alexander, Veronica
Suresh, Priyanka
Mitchell, George
Macpherson, Calum
Gérardin, Patrick
LaBeaud, A. Desiree
author_sort Waechter, Randall
collection PubMed
description BACKGROUND: The 2005–06 chikungunya virus (CHIKV) outbreak in La Réunion suggested that mothers could transmit CHIKV to their neonates while viremic during the intrapartum period, and more than half of the infected neonates showed impaired neurodevelopment at two years of age. However, data sparsity precluded an overview of the developmental impact of vertical infection within the whole prenatal period. OBJECTIVE & METHODS: The current study assessed two-year old children born to mothers who were infected during the 2014 CHIKV outbreak in Grenada to determine the neurodevelopmental impact of perinatal CHIKV infection throughout gestation. Mother and child infection status were confirmed by serologic testing (IgG and IgM) for CHIKV. Cognitive, fine motor, gross motor, language and behavioral outcomes were assessed at two years of age on the INTERGROWTH-21(st) Neurodevelopment Assessment (INTER-NDA). RESULTS: No differences in neurodevelopmental outcomes were observed between two-year-old children born to mothers infected with CHIKV during gestation (n = 149) and those born to mothers not infected with CHIKV (n = 161). No differences were found in INTER-NDA scores between children infected with CHIKV (n = 47) and children not infected with CHIKV (n = 592). Likewise, there were no differences between children infected with CHIKV post-partum (n = 19) versus children not infected with CHIKV (n = 592). CONCLUSION: Our findings suggest that children exposed and/or infected with CHIKV outside of the intrapartum period experience no significant neurodevelopmental delay at two years of age, as measured by the INTER-NDA, compared to their unexposed and/or uninfected peers. These results complement those of previous studies which showed a neurodevelopmental risk only for children infected during the intrapartum period, while the mother was highly viremic. These results might be reassuring for women of childbearing age and public health officials in CHIKV-endemic regions.
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spelling pubmed-75350672020-10-15 Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age Waechter, Randall Ingraham, Erinique Evans, Roberta Cudjoe, Nikita Krystosik, Amy Isaac, Rashida Watts, Ashlee Noël, Trevor Landon, Barbara Fernandes, Michelle Mapp-Alexander, Veronica Suresh, Priyanka Mitchell, George Macpherson, Calum Gérardin, Patrick LaBeaud, A. Desiree PLoS Negl Trop Dis Research Article BACKGROUND: The 2005–06 chikungunya virus (CHIKV) outbreak in La Réunion suggested that mothers could transmit CHIKV to their neonates while viremic during the intrapartum period, and more than half of the infected neonates showed impaired neurodevelopment at two years of age. However, data sparsity precluded an overview of the developmental impact of vertical infection within the whole prenatal period. OBJECTIVE & METHODS: The current study assessed two-year old children born to mothers who were infected during the 2014 CHIKV outbreak in Grenada to determine the neurodevelopmental impact of perinatal CHIKV infection throughout gestation. Mother and child infection status were confirmed by serologic testing (IgG and IgM) for CHIKV. Cognitive, fine motor, gross motor, language and behavioral outcomes were assessed at two years of age on the INTERGROWTH-21(st) Neurodevelopment Assessment (INTER-NDA). RESULTS: No differences in neurodevelopmental outcomes were observed between two-year-old children born to mothers infected with CHIKV during gestation (n = 149) and those born to mothers not infected with CHIKV (n = 161). No differences were found in INTER-NDA scores between children infected with CHIKV (n = 47) and children not infected with CHIKV (n = 592). Likewise, there were no differences between children infected with CHIKV post-partum (n = 19) versus children not infected with CHIKV (n = 592). CONCLUSION: Our findings suggest that children exposed and/or infected with CHIKV outside of the intrapartum period experience no significant neurodevelopmental delay at two years of age, as measured by the INTER-NDA, compared to their unexposed and/or uninfected peers. These results complement those of previous studies which showed a neurodevelopmental risk only for children infected during the intrapartum period, while the mother was highly viremic. These results might be reassuring for women of childbearing age and public health officials in CHIKV-endemic regions. Public Library of Science 2020-10-05 /pmc/articles/PMC7535067/ /pubmed/33017393 http://dx.doi.org/10.1371/journal.pntd.0008546 Text en © 2020 Waechter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Waechter, Randall
Ingraham, Erinique
Evans, Roberta
Cudjoe, Nikita
Krystosik, Amy
Isaac, Rashida
Watts, Ashlee
Noël, Trevor
Landon, Barbara
Fernandes, Michelle
Mapp-Alexander, Veronica
Suresh, Priyanka
Mitchell, George
Macpherson, Calum
Gérardin, Patrick
LaBeaud, A. Desiree
Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title_full Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title_fullStr Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title_full_unstemmed Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title_short Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
title_sort pre and postnatal exposure to chikungunya virus does not affect child neurodevelopmental outcomes at two years of age
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535067/
https://www.ncbi.nlm.nih.gov/pubmed/33017393
http://dx.doi.org/10.1371/journal.pntd.0008546
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