The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO(2)-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that Ce...

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Detalles Bibliográficos
Autores principales: Li, Hongru, Xia, Peng, Pan, Su, Qi, Zhiping, Fu, Chuan, Yu, Ziyuan, Kong, Weijian, Chang, Yuxin, Wang, Kai, Wu, Dankai, Yang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535115/
https://www.ncbi.nlm.nih.gov/pubmed/33061376
http://dx.doi.org/10.2147/IJN.S270229
Descripción
Sumario:The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO(2)-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO(2)-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO(2)-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO(2)-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO(2)-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO(2)-NPs.

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