Minodronate in the treatment of osteoporosis: A systematic review and meta-analysis

BACKGROUND: The goal of this study was to review relevant randomized controlled trials or case-control studies to determine the clinical efficacy of minodronate in the treatment of osteoporosis. METHOD: The relevant studies were identified on PubMed, Cochrane, and Embase databases using appropriate keywords. Pertinent sources in the literature were also reviewed, and all articles published through October 2019 were considered for inclusion. For each study, we assessed odds ratios, mean difference, and 95% confidence interval (95% CI) to evaluate and synthesize outcomes. RESULT: Thirteen studies comprising 3740 patients were included in this study. Compared with other drugs, minodronate significantly decreased N-telopeptide of type I collagen/creatinine (weighted mean difference [WMD]: –13.669, 95% confidence interval [CI]: –23.108 to –4.229), bone alkaline phosphatase (BAP) (WMD: –1.26, 95% CI: –2.04 to –0.47) and tartrate-resistant acid phosphatase 5b (WMD: –154.11, 95% CI: –277.85 to –30.37). Minodronate combined with other drugs would significantly decrease BAP (WMD: –3.10, 95% CI: –5.20 to –1.00) than minodronate. Minodronate-naïve would significantly decrease BAP (WMD: –3.00, 95% CI: –5.47 to 0.53) and tartrate-resistant acid phosphatase 5b (WMD: –128.20, 95% CI: –198.11 to –58.29) than minodronate-switch. The incidence of vertebral fracture was significantly decreased in the minodronate group than the other drugs (relative risk: 0.520, 95% CI: 0.363–0.744). CONCLUSION: Minodronate has better clinical efficacy in the treatment of osteoporosis than other drugs (alendronate, risedronate, raloxifene, or eldecalcitol).