Tacrolimus-Induced Acute Esophageal Necrosis

Acute esophageal necrosis (AEN) has been rarely described and has poorly understood pathophysiology although it is thought to be related to mucosal defense barrier disruption. We report a case of AEN in a 71-year-old patient with clinical signs of gastric outlet obstruction along with anemia and sep...

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Detalles Bibliográficos
Autores principales: Wanta, Kaitlin, Abegunde, Ayokunle T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535755/
https://www.ncbi.nlm.nih.gov/pubmed/33062774
http://dx.doi.org/10.14309/crj.0000000000000396
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author Wanta, Kaitlin
Abegunde, Ayokunle T.
author_facet Wanta, Kaitlin
Abegunde, Ayokunle T.
author_sort Wanta, Kaitlin
collection PubMed
description Acute esophageal necrosis (AEN) has been rarely described and has poorly understood pathophysiology although it is thought to be related to mucosal defense barrier disruption. We report a case of AEN in a 71-year-old patient with clinical signs of gastric outlet obstruction along with anemia and sepsis in the setting of a recent kidney transplant. After failing standard supportive measures, tacrolimus was switched to cyclosporin with overall rapid improvement of AEN and concomitant duodenal ulcerations. This case underscores a possible rare adverse effect of a commonly used immunosuppressant agent that, to our knowledge, has not been specifically reported.
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spelling pubmed-75357552020-10-14 Tacrolimus-Induced Acute Esophageal Necrosis Wanta, Kaitlin Abegunde, Ayokunle T. ACG Case Rep J Case Report Acute esophageal necrosis (AEN) has been rarely described and has poorly understood pathophysiology although it is thought to be related to mucosal defense barrier disruption. We report a case of AEN in a 71-year-old patient with clinical signs of gastric outlet obstruction along with anemia and sepsis in the setting of a recent kidney transplant. After failing standard supportive measures, tacrolimus was switched to cyclosporin with overall rapid improvement of AEN and concomitant duodenal ulcerations. This case underscores a possible rare adverse effect of a commonly used immunosuppressant agent that, to our knowledge, has not been specifically reported. Wolters Kluwer 2020-06-25 /pmc/articles/PMC7535755/ /pubmed/33062774 http://dx.doi.org/10.14309/crj.0000000000000396 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Wanta, Kaitlin
Abegunde, Ayokunle T.
Tacrolimus-Induced Acute Esophageal Necrosis
title Tacrolimus-Induced Acute Esophageal Necrosis
title_full Tacrolimus-Induced Acute Esophageal Necrosis
title_fullStr Tacrolimus-Induced Acute Esophageal Necrosis
title_full_unstemmed Tacrolimus-Induced Acute Esophageal Necrosis
title_short Tacrolimus-Induced Acute Esophageal Necrosis
title_sort tacrolimus-induced acute esophageal necrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535755/
https://www.ncbi.nlm.nih.gov/pubmed/33062774
http://dx.doi.org/10.14309/crj.0000000000000396
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