Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?

Amoxicillin-clavulanate has long been associated with drug-induced liver injury (DILI) and although approximately 4 times less common, amoxicillin has also been implicated. Many studies have associated possible genetic factors with susceptibility to DILI, but there is currently no literature with ev...

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Detalles Bibliográficos
Autores principales: Schosheim, Alexander, Mockler, Daniel, Chawla, Anupama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535757/
https://www.ncbi.nlm.nih.gov/pubmed/33062772
http://dx.doi.org/10.14309/crj.0000000000000389
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author Schosheim, Alexander
Mockler, Daniel
Chawla, Anupama
author_facet Schosheim, Alexander
Mockler, Daniel
Chawla, Anupama
author_sort Schosheim, Alexander
collection PubMed
description Amoxicillin-clavulanate has long been associated with drug-induced liver injury (DILI) and although approximately 4 times less common, amoxicillin has also been implicated. Many studies have associated possible genetic factors with susceptibility to DILI, but there is currently no literature with evidence of instances of DILI within the same family. Two sisters presented with similar symptoms and signs of liver injury including jaundice, scleral icterus, abdominal pain, and anorexia with transaminitis and abnormal coagulation studies. Both sisters were started on amoxicillin approximately 2–3 weeks before presentation. They both had progression of the liver injury, and on biopsies, they had similar findings indicative of DILI as well.
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spelling pubmed-75357572020-10-14 Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure? Schosheim, Alexander Mockler, Daniel Chawla, Anupama ACG Case Rep J Case Report Amoxicillin-clavulanate has long been associated with drug-induced liver injury (DILI) and although approximately 4 times less common, amoxicillin has also been implicated. Many studies have associated possible genetic factors with susceptibility to DILI, but there is currently no literature with evidence of instances of DILI within the same family. Two sisters presented with similar symptoms and signs of liver injury including jaundice, scleral icterus, abdominal pain, and anorexia with transaminitis and abnormal coagulation studies. Both sisters were started on amoxicillin approximately 2–3 weeks before presentation. They both had progression of the liver injury, and on biopsies, they had similar findings indicative of DILI as well. Wolters Kluwer 2020-06-16 /pmc/articles/PMC7535757/ /pubmed/33062772 http://dx.doi.org/10.14309/crj.0000000000000389 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Schosheim, Alexander
Mockler, Daniel
Chawla, Anupama
Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title_full Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title_fullStr Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title_full_unstemmed Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title_short Does Genetics Play a Role in Acute Liver Injury After Amoxicillin Exposure?
title_sort does genetics play a role in acute liver injury after amoxicillin exposure?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535757/
https://www.ncbi.nlm.nih.gov/pubmed/33062772
http://dx.doi.org/10.14309/crj.0000000000000389
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AT chawlaanupama doesgeneticsplayaroleinacuteliverinjuryafteramoxicillinexposure

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