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The genetic factors of bilaterian evolution
The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative geno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535936/ https://www.ncbi.nlm.nih.gov/pubmed/32672535 http://dx.doi.org/10.7554/eLife.45530 |
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author | Heger, Peter Zheng, Wen Rottmann, Anna Panfilio, Kristen A Wiehe, Thomas |
author_facet | Heger, Peter Zheng, Wen Rottmann, Anna Panfilio, Kristen A Wiehe, Thomas |
author_sort | Heger, Peter |
collection | PubMed |
description | The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship. |
format | Online Article Text |
id | pubmed-7535936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-75359362020-10-07 The genetic factors of bilaterian evolution Heger, Peter Zheng, Wen Rottmann, Anna Panfilio, Kristen A Wiehe, Thomas eLife Evolutionary Biology The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship. eLife Sciences Publications, Ltd 2020-07-16 /pmc/articles/PMC7535936/ /pubmed/32672535 http://dx.doi.org/10.7554/eLife.45530 Text en © 2020, Heger et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Heger, Peter Zheng, Wen Rottmann, Anna Panfilio, Kristen A Wiehe, Thomas The genetic factors of bilaterian evolution |
title | The genetic factors of bilaterian evolution |
title_full | The genetic factors of bilaterian evolution |
title_fullStr | The genetic factors of bilaterian evolution |
title_full_unstemmed | The genetic factors of bilaterian evolution |
title_short | The genetic factors of bilaterian evolution |
title_sort | genetic factors of bilaterian evolution |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535936/ https://www.ncbi.nlm.nih.gov/pubmed/32672535 http://dx.doi.org/10.7554/eLife.45530 |
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