Insight into m(6)A methylation from occurrence to functions

RNA m(6)A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukary...

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Autores principales: Ru, Wenxiu, Zhang, Xiaoyan, Yue, Binglin, Qi, Ao, Shen, Xuemei, Huang, Yongzhen, Lan, Xianyong, Lei, Chuzhao, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536083/
https://www.ncbi.nlm.nih.gov/pubmed/32898471
http://dx.doi.org/10.1098/rsob.200091
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author Ru, Wenxiu
Zhang, Xiaoyan
Yue, Binglin
Qi, Ao
Shen, Xuemei
Huang, Yongzhen
Lan, Xianyong
Lei, Chuzhao
Chen, Hong
author_facet Ru, Wenxiu
Zhang, Xiaoyan
Yue, Binglin
Qi, Ao
Shen, Xuemei
Huang, Yongzhen
Lan, Xianyong
Lei, Chuzhao
Chen, Hong
author_sort Ru, Wenxiu
collection PubMed
description RNA m(6)A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m(6)A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m(6)A, and briefly introduce the mammalian m(6)A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m(6)A and the outstanding questions about the regulatory effect of this widespread modification.
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spelling pubmed-75360832020-10-09 Insight into m(6)A methylation from occurrence to functions Ru, Wenxiu Zhang, Xiaoyan Yue, Binglin Qi, Ao Shen, Xuemei Huang, Yongzhen Lan, Xianyong Lei, Chuzhao Chen, Hong Open Biol Review RNA m(6)A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m(6)A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m(6)A, and briefly introduce the mammalian m(6)A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m(6)A and the outstanding questions about the regulatory effect of this widespread modification. The Royal Society 2020-09-09 /pmc/articles/PMC7536083/ /pubmed/32898471 http://dx.doi.org/10.1098/rsob.200091 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Ru, Wenxiu
Zhang, Xiaoyan
Yue, Binglin
Qi, Ao
Shen, Xuemei
Huang, Yongzhen
Lan, Xianyong
Lei, Chuzhao
Chen, Hong
Insight into m(6)A methylation from occurrence to functions
title Insight into m(6)A methylation from occurrence to functions
title_full Insight into m(6)A methylation from occurrence to functions
title_fullStr Insight into m(6)A methylation from occurrence to functions
title_full_unstemmed Insight into m(6)A methylation from occurrence to functions
title_short Insight into m(6)A methylation from occurrence to functions
title_sort insight into m(6)a methylation from occurrence to functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536083/
https://www.ncbi.nlm.nih.gov/pubmed/32898471
http://dx.doi.org/10.1098/rsob.200091
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