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Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with micro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536321/ https://www.ncbi.nlm.nih.gov/pubmed/33072760 http://dx.doi.org/10.3389/fcell.2020.578239 |
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author | Vitre, Benjamin Guesdon, Audrey Delaval, Benedicte |
author_facet | Vitre, Benjamin Guesdon, Audrey Delaval, Benedicte |
author_sort | Vitre, Benjamin |
collection | PubMed |
description | Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with microtubules and motors. If IFT proteins have long been studied for their ciliary roles, recent evidences indicate that their functions are not restricted to the cilium. Indeed, IFT proteins are found outside the ciliary compartment where they are involved in a variety of cellular processes in association with non-ciliary motors. Recent works also provide evidence that non-ciliary roles of IFT proteins could be responsible for the development of ciliopathies related phenotypes including polycystic kidney diseases. In this review, we will discuss the interactions of IFT proteins with microtubules and motors as well as newly identified non-ciliary functions of IFT proteins, focusing on their roles in cell division. We will also discuss the potential contribution of non-ciliary IFT proteins functions to the etiology of kidney diseases. |
format | Online Article Text |
id | pubmed-7536321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75363212020-10-16 Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases Vitre, Benjamin Guesdon, Audrey Delaval, Benedicte Front Cell Dev Biol Cell and Developmental Biology Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with microtubules and motors. If IFT proteins have long been studied for their ciliary roles, recent evidences indicate that their functions are not restricted to the cilium. Indeed, IFT proteins are found outside the ciliary compartment where they are involved in a variety of cellular processes in association with non-ciliary motors. Recent works also provide evidence that non-ciliary roles of IFT proteins could be responsible for the development of ciliopathies related phenotypes including polycystic kidney diseases. In this review, we will discuss the interactions of IFT proteins with microtubules and motors as well as newly identified non-ciliary functions of IFT proteins, focusing on their roles in cell division. We will also discuss the potential contribution of non-ciliary IFT proteins functions to the etiology of kidney diseases. Frontiers Media S.A. 2020-09-22 /pmc/articles/PMC7536321/ /pubmed/33072760 http://dx.doi.org/10.3389/fcell.2020.578239 Text en Copyright © 2020 Vitre, Guesdon and Delaval. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Vitre, Benjamin Guesdon, Audrey Delaval, Benedicte Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title | Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title_full | Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title_fullStr | Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title_full_unstemmed | Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title_short | Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases |
title_sort | non-ciliary roles of ift proteins in cell division and polycystic kidney diseases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536321/ https://www.ncbi.nlm.nih.gov/pubmed/33072760 http://dx.doi.org/10.3389/fcell.2020.578239 |
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