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Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases

Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with micro...

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Autores principales: Vitre, Benjamin, Guesdon, Audrey, Delaval, Benedicte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536321/
https://www.ncbi.nlm.nih.gov/pubmed/33072760
http://dx.doi.org/10.3389/fcell.2020.578239
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author Vitre, Benjamin
Guesdon, Audrey
Delaval, Benedicte
author_facet Vitre, Benjamin
Guesdon, Audrey
Delaval, Benedicte
author_sort Vitre, Benjamin
collection PubMed
description Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with microtubules and motors. If IFT proteins have long been studied for their ciliary roles, recent evidences indicate that their functions are not restricted to the cilium. Indeed, IFT proteins are found outside the ciliary compartment where they are involved in a variety of cellular processes in association with non-ciliary motors. Recent works also provide evidence that non-ciliary roles of IFT proteins could be responsible for the development of ciliopathies related phenotypes including polycystic kidney diseases. In this review, we will discuss the interactions of IFT proteins with microtubules and motors as well as newly identified non-ciliary functions of IFT proteins, focusing on their roles in cell division. We will also discuss the potential contribution of non-ciliary IFT proteins functions to the etiology of kidney diseases.
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spelling pubmed-75363212020-10-16 Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases Vitre, Benjamin Guesdon, Audrey Delaval, Benedicte Front Cell Dev Biol Cell and Developmental Biology Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport system that functions in association with microtubules and motors. If IFT proteins have long been studied for their ciliary roles, recent evidences indicate that their functions are not restricted to the cilium. Indeed, IFT proteins are found outside the ciliary compartment where they are involved in a variety of cellular processes in association with non-ciliary motors. Recent works also provide evidence that non-ciliary roles of IFT proteins could be responsible for the development of ciliopathies related phenotypes including polycystic kidney diseases. In this review, we will discuss the interactions of IFT proteins with microtubules and motors as well as newly identified non-ciliary functions of IFT proteins, focusing on their roles in cell division. We will also discuss the potential contribution of non-ciliary IFT proteins functions to the etiology of kidney diseases. Frontiers Media S.A. 2020-09-22 /pmc/articles/PMC7536321/ /pubmed/33072760 http://dx.doi.org/10.3389/fcell.2020.578239 Text en Copyright © 2020 Vitre, Guesdon and Delaval. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Vitre, Benjamin
Guesdon, Audrey
Delaval, Benedicte
Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title_full Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title_fullStr Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title_full_unstemmed Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title_short Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
title_sort non-ciliary roles of ift proteins in cell division and polycystic kidney diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536321/
https://www.ncbi.nlm.nih.gov/pubmed/33072760
http://dx.doi.org/10.3389/fcell.2020.578239
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