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Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardio...

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Autores principales: Zemrak, Filip, Raisi-Estabragh, Zahra, Khanji, Mohammed Y., Mohiddin, Saidi A., Bruder, Oliver, Wagner, Anja, Lombardi, Massimo, Schwitter, Juerg, van Rossum, Albert C., Pilz, Günter, Nothnagel, Detlev, Steen, Henning, Nagel, Eike, Prasad, Sanjay K., Deluigi, Christina C., Dill, Thorsten, Frank, Herbert, Schneider, Steffen, Mahrholdt, Heiko, Petersen, Steffen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536335/
https://www.ncbi.nlm.nih.gov/pubmed/33195445
http://dx.doi.org/10.3389/fcvm.2020.00158
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author Zemrak, Filip
Raisi-Estabragh, Zahra
Khanji, Mohammed Y.
Mohiddin, Saidi A.
Bruder, Oliver
Wagner, Anja
Lombardi, Massimo
Schwitter, Juerg
van Rossum, Albert C.
Pilz, Günter
Nothnagel, Detlev
Steen, Henning
Nagel, Eike
Prasad, Sanjay K.
Deluigi, Christina C.
Dill, Thorsten
Frank, Herbert
Schneider, Steffen
Mahrholdt, Heiko
Petersen, Steffen E.
author_facet Zemrak, Filip
Raisi-Estabragh, Zahra
Khanji, Mohammed Y.
Mohiddin, Saidi A.
Bruder, Oliver
Wagner, Anja
Lombardi, Massimo
Schwitter, Juerg
van Rossum, Albert C.
Pilz, Günter
Nothnagel, Detlev
Steen, Henning
Nagel, Eike
Prasad, Sanjay K.
Deluigi, Christina C.
Dill, Thorsten
Frank, Herbert
Schneider, Steffen
Mahrholdt, Heiko
Petersen, Steffen E.
author_sort Zemrak, Filip
collection PubMed
description Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3. Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.
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spelling pubmed-75363352020-11-13 Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry Zemrak, Filip Raisi-Estabragh, Zahra Khanji, Mohammed Y. Mohiddin, Saidi A. Bruder, Oliver Wagner, Anja Lombardi, Massimo Schwitter, Juerg van Rossum, Albert C. Pilz, Günter Nothnagel, Detlev Steen, Henning Nagel, Eike Prasad, Sanjay K. Deluigi, Christina C. Dill, Thorsten Frank, Herbert Schneider, Steffen Mahrholdt, Heiko Petersen, Steffen E. Front Cardiovasc Med Cardiovascular Medicine Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3. Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis. Frontiers Media S.A. 2020-09-22 /pmc/articles/PMC7536335/ /pubmed/33195445 http://dx.doi.org/10.3389/fcvm.2020.00158 Text en Copyright © 2020 Zemrak, Raisi-Estabragh, Khanji, Mohiddin, Bruder, Wagner, Lombardi, Schwitter, van Rossum, Pilz, Nothnagel, Steen, Nagel, Prasad, Deluigi, Dill, Frank, Schneider, Mahrholdt and Petersen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zemrak, Filip
Raisi-Estabragh, Zahra
Khanji, Mohammed Y.
Mohiddin, Saidi A.
Bruder, Oliver
Wagner, Anja
Lombardi, Massimo
Schwitter, Juerg
van Rossum, Albert C.
Pilz, Günter
Nothnagel, Detlev
Steen, Henning
Nagel, Eike
Prasad, Sanjay K.
Deluigi, Christina C.
Dill, Thorsten
Frank, Herbert
Schneider, Steffen
Mahrholdt, Heiko
Petersen, Steffen E.
Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title_full Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title_fullStr Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title_full_unstemmed Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title_short Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
title_sort left ventricular hypertrabeculation is not associated with cardiovascular morbity or mortality: insights from the eurocmr registry
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536335/
https://www.ncbi.nlm.nih.gov/pubmed/33195445
http://dx.doi.org/10.3389/fcvm.2020.00158
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