FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

The expression of short chain fatty acid receptors FFA2 and FFA3 in pancreatic islets raised interest in using them as drug targets for treating hyperglycemia in humans. This study aims to examine the efficacy of synthetic FFA2- and FFA3-ligands to modulate glucose-stimulated insulin secretion (GSIS...

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Detalles Bibliográficos
Autores principales: Lorza-Gil, Estela, Kaiser, Gabriele, Rexen Ulven, Elisabeth, König, Gabriele M., Gerst, Felicia, Oquendo, Morgana Barroso, Birkenfeld, Andreas L., Häring, Hans-Ulrich, Kostenis, Evi, Ulven, Trond, Ullrich, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536384/
https://www.ncbi.nlm.nih.gov/pubmed/33020504
http://dx.doi.org/10.1038/s41598-020-73467-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536384/
https://www.ncbi.nlm.nih.gov/pubmed/33020504
http://dx.doi.org/10.1038/s41598-020-73467-5

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