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Severe Wernicke encephalopathy and acute pancreatitis due to all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic leukaemia: a case report
A 55-year-old woman developed acute promyelocytic leukaemia during treatment with all-trans-retinoic acid and arsenic trioxide. Initially, she presented with symptoms of epigastric pain, vomiting, and nausea, and she developed acute pancreatitis. She was treated with parenteral nutritional supplemen...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536494/ https://www.ncbi.nlm.nih.gov/pubmed/32993392 http://dx.doi.org/10.1177/0300060520959487 |
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author | Jiang, Yan Ji, Linhua |
author_facet | Jiang, Yan Ji, Linhua |
author_sort | Jiang, Yan |
collection | PubMed |
description | A 55-year-old woman developed acute promyelocytic leukaemia during treatment with all-trans-retinoic acid and arsenic trioxide. Initially, she presented with symptoms of epigastric pain, vomiting, and nausea, and she developed acute pancreatitis. She was treated with parenteral nutritional supplementation for 20 days. However, the patient continued to develop refractory hyponatraemia, hypotension, and apathy. Finally, the patient was diagnosed with Wernicke encephalopathy (WE) using head magnetic resonance imaging. The patient underwent high-dose intravenous thiamine administration, and her symptoms were alleviated. WE is a rare adverse event during acute pancreatitis therapy. Acute pancreatitis that is caused by all-trans-retinoic acid and arsenic trioxide is a rare complication of acute promyelocytic leukaemia during chemotherapy. Further study is essential to improve our comprehension of the risk factors for complications in patients with acute promyelocytic leukaemia, considering that the associated complications were potentially caused by multiple etiological factors. A better understanding of these risk factors may help to improve the prognosis of patients with acute promyelocytic leukaemia at an early stage. |
format | Online Article Text |
id | pubmed-7536494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75364942020-10-14 Severe Wernicke encephalopathy and acute pancreatitis due to all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic leukaemia: a case report Jiang, Yan Ji, Linhua J Int Med Res Case Report A 55-year-old woman developed acute promyelocytic leukaemia during treatment with all-trans-retinoic acid and arsenic trioxide. Initially, she presented with symptoms of epigastric pain, vomiting, and nausea, and she developed acute pancreatitis. She was treated with parenteral nutritional supplementation for 20 days. However, the patient continued to develop refractory hyponatraemia, hypotension, and apathy. Finally, the patient was diagnosed with Wernicke encephalopathy (WE) using head magnetic resonance imaging. The patient underwent high-dose intravenous thiamine administration, and her symptoms were alleviated. WE is a rare adverse event during acute pancreatitis therapy. Acute pancreatitis that is caused by all-trans-retinoic acid and arsenic trioxide is a rare complication of acute promyelocytic leukaemia during chemotherapy. Further study is essential to improve our comprehension of the risk factors for complications in patients with acute promyelocytic leukaemia, considering that the associated complications were potentially caused by multiple etiological factors. A better understanding of these risk factors may help to improve the prognosis of patients with acute promyelocytic leukaemia at an early stage. SAGE Publications 2020-09-30 /pmc/articles/PMC7536494/ /pubmed/32993392 http://dx.doi.org/10.1177/0300060520959487 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Jiang, Yan Ji, Linhua Severe Wernicke encephalopathy and acute pancreatitis due to all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic leukaemia: a case report |
title | Severe Wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
title_full | Severe Wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
title_fullStr | Severe Wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
title_full_unstemmed | Severe Wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
title_short | Severe Wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
title_sort | severe wernicke encephalopathy and acute pancreatitis due to
all-trans-retinoic acid and arsenic trioxide during treatment of acute promyelocytic
leukaemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536494/ https://www.ncbi.nlm.nih.gov/pubmed/32993392 http://dx.doi.org/10.1177/0300060520959487 |
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