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Canadian society of clinical chemists (CSCC) interim consensus guidance for testing and reporting of SARS-CoV-2 serology

Clinical laboratories across the world are working to validate and perform testing for SARS-CoV-2 antibodies. Herein, we present interim consensus guidance for Canadian clinical laboratories testing and reporting SARS-CoV-2 serology, with emphasis on the capabilities and limitations of these tests a...

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Detalles Bibliográficos
Autores principales: Bailey, Dana, Konforte, Danijela, Barakauskas, Vilte E., Yip, Paul M., Kulasingam, Vathany, Abou El Hassan, Mohamed, Beach, Lori A., Blasutig, Ivan M., Catomeris, Peter, Dooley, Kent C., Gong, Yanping, Kavsak, Peter, Randell, Edward W., Robinson, Jason L., Shaw, Julie, Taher, Jennifer, White-Al Habeeb, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536550/
https://www.ncbi.nlm.nih.gov/pubmed/33031819
http://dx.doi.org/10.1016/j.clinbiochem.2020.09.005
Descripción
Sumario:Clinical laboratories across the world are working to validate and perform testing for SARS-CoV-2 antibodies. Herein, we present interim consensus guidance for Canadian clinical laboratories testing and reporting SARS-CoV-2 serology, with emphasis on the capabilities and limitations of these tests and recommendations for interpretative comments in an effort to achieve harmonized laboratory practices. The consensus document provides a broad overview of topics including sample type and contamination risk; kinetics of antibody response to COVID-19 and the impact on serology testing; clinical utility of SARS-CoV-2 serology testing; clinical performance of commercial laboratory-based assays commonly deployed in North America; recommendations for interim reporting; utility of SARS-CoV-2 antibody testing for pediatric patients; and utility of point-of-care testing. The information is based on the current literature and is subject to change as additional information becomes available.