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Tumors associated with radiotherapy: a case series
BACKGROUND: Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, there is an age-standardized incidence rate of 44 per 100,000 women. Radiotherapy...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537103/ https://www.ncbi.nlm.nih.gov/pubmed/33019945 http://dx.doi.org/10.1186/s13256-020-02482-x |
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author | Garcia, Mauricio Hernandez, Dary L. Mendoza, Sara Buelvas, Nelson Alvarez, Angelina Esguerra, Jose Díaz, Sandra |
author_facet | Garcia, Mauricio Hernandez, Dary L. Mendoza, Sara Buelvas, Nelson Alvarez, Angelina Esguerra, Jose Díaz, Sandra |
author_sort | Garcia, Mauricio |
collection | PubMed |
description | BACKGROUND: Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, there is an age-standardized incidence rate of 44 per 100,000 women. Radiotherapy improves local and regional control in patients with breast cancer, and it could even improve relapse-free survival and overall survival in patients with nodal disease. The toxicity of this treatment in most cases is mild and transient, but in a low percentage of patients, radiotherapy-induced tumors may develop. CASE PRESENTATION: Seven Colombian patients treated for breast cancer at our institution developed radiotherapy-induced tumors between 2008 and 2018. The median age was 54.4 (range 35–72) years. Six patients had locally advanced tumors at the time breast cancer was diagnosed, and all of them received neoadjuvant or adjuvant chemotherapy and radiotherapy. The radiotherapy-induced tumors were five sarcomas, one of which was a well-differentiated angiosarcomatous vascular lesion with negative c-Myc (benign lesion), and the remaining patient had basal cell carcinoma associated with radiotherapy. CONCLUSIONS: Sarcomas are the most common radiotherapy-induced tumors after breast cancer treatment. These are rare, aggressive tumors and represent between 0.5% and 5.5% of all sarcomas. Basal cell carcinoma has also been associated with breast cancer treatment. The management is individualized and multimodal, including surgical resection and chemotherapy. Different studies have shown that radiation therapy is a risk factor for the development of soft tissue tumors. |
format | Online Article Text |
id | pubmed-7537103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75371032020-10-08 Tumors associated with radiotherapy: a case series Garcia, Mauricio Hernandez, Dary L. Mendoza, Sara Buelvas, Nelson Alvarez, Angelina Esguerra, Jose Díaz, Sandra J Med Case Rep Case Report BACKGROUND: Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, there is an age-standardized incidence rate of 44 per 100,000 women. Radiotherapy improves local and regional control in patients with breast cancer, and it could even improve relapse-free survival and overall survival in patients with nodal disease. The toxicity of this treatment in most cases is mild and transient, but in a low percentage of patients, radiotherapy-induced tumors may develop. CASE PRESENTATION: Seven Colombian patients treated for breast cancer at our institution developed radiotherapy-induced tumors between 2008 and 2018. The median age was 54.4 (range 35–72) years. Six patients had locally advanced tumors at the time breast cancer was diagnosed, and all of them received neoadjuvant or adjuvant chemotherapy and radiotherapy. The radiotherapy-induced tumors were five sarcomas, one of which was a well-differentiated angiosarcomatous vascular lesion with negative c-Myc (benign lesion), and the remaining patient had basal cell carcinoma associated with radiotherapy. CONCLUSIONS: Sarcomas are the most common radiotherapy-induced tumors after breast cancer treatment. These are rare, aggressive tumors and represent between 0.5% and 5.5% of all sarcomas. Basal cell carcinoma has also been associated with breast cancer treatment. The management is individualized and multimodal, including surgical resection and chemotherapy. Different studies have shown that radiation therapy is a risk factor for the development of soft tissue tumors. BioMed Central 2020-10-06 /pmc/articles/PMC7537103/ /pubmed/33019945 http://dx.doi.org/10.1186/s13256-020-02482-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Garcia, Mauricio Hernandez, Dary L. Mendoza, Sara Buelvas, Nelson Alvarez, Angelina Esguerra, Jose Díaz, Sandra Tumors associated with radiotherapy: a case series |
title | Tumors associated with radiotherapy: a case series |
title_full | Tumors associated with radiotherapy: a case series |
title_fullStr | Tumors associated with radiotherapy: a case series |
title_full_unstemmed | Tumors associated with radiotherapy: a case series |
title_short | Tumors associated with radiotherapy: a case series |
title_sort | tumors associated with radiotherapy: a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537103/ https://www.ncbi.nlm.nih.gov/pubmed/33019945 http://dx.doi.org/10.1186/s13256-020-02482-x |
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