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Naturally activated adaptive immunity in COVID‐19 patients

Coronavirus disease‐2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) has rapidly spread worldwide, threatening the health and lives of many people. Unfortunately, information regarding the immunological characteristics of COVID‐19 patients remains limited. Herein,...

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Autores principales: Yang, Xiaofeng, Dai, Tongxin, Zhou, Xiaobo, Qian, Hongbo, Guo, Rui, Lei, Lei, Zhang, Xingzhe, Zhang, Dan, Shi, Lin, Cheng, Yanbin, Hu, Jinsong, Guo, Yaling, Zhang, Baojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537162/
https://www.ncbi.nlm.nih.gov/pubmed/32975374
http://dx.doi.org/10.1111/jcmm.15771
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author Yang, Xiaofeng
Dai, Tongxin
Zhou, Xiaobo
Qian, Hongbo
Guo, Rui
Lei, Lei
Zhang, Xingzhe
Zhang, Dan
Shi, Lin
Cheng, Yanbin
Hu, Jinsong
Guo, Yaling
Zhang, Baojun
author_facet Yang, Xiaofeng
Dai, Tongxin
Zhou, Xiaobo
Qian, Hongbo
Guo, Rui
Lei, Lei
Zhang, Xingzhe
Zhang, Dan
Shi, Lin
Cheng, Yanbin
Hu, Jinsong
Guo, Yaling
Zhang, Baojun
author_sort Yang, Xiaofeng
collection PubMed
description Coronavirus disease‐2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) has rapidly spread worldwide, threatening the health and lives of many people. Unfortunately, information regarding the immunological characteristics of COVID‐19 patients remains limited. Herein, we collected blood samples from 18 healthy donors (HDs) and 38 COVID‐19 patients to analyse changes in the adaptive immune cell populations and their phenotypes. We observed that the lymphocyte percentage moderately decreased, CD4 and CD8 T cell percentage among lymphocytes were similar, and B cell percentage was increased in COVID‐19 patients in comparison to that in HDs. T cells, especially CD8 T cells, showed an enhanced expression of late activation marker CD25 and exhaustion marker PD‐1. Importantly, SARS‐CoV‐2 infection increased the percentage of T follicular helper– and germinal centre B–like cells in the blood. The parameters in COVID‐19 patients remained unchanged across various age groups. Therefore, we demonstrated that the T and B cells are activated naturally and are functional during SARS‐CoV‐2 infection. These data provide evidence that the adaptive immunity in most patients could be primed to induce a significant immune response against SARS‐CoV‐2 infection upon receiving standard medical care.
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spelling pubmed-75371622020-10-07 Naturally activated adaptive immunity in COVID‐19 patients Yang, Xiaofeng Dai, Tongxin Zhou, Xiaobo Qian, Hongbo Guo, Rui Lei, Lei Zhang, Xingzhe Zhang, Dan Shi, Lin Cheng, Yanbin Hu, Jinsong Guo, Yaling Zhang, Baojun J Cell Mol Med Original Articles Coronavirus disease‐2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) has rapidly spread worldwide, threatening the health and lives of many people. Unfortunately, information regarding the immunological characteristics of COVID‐19 patients remains limited. Herein, we collected blood samples from 18 healthy donors (HDs) and 38 COVID‐19 patients to analyse changes in the adaptive immune cell populations and their phenotypes. We observed that the lymphocyte percentage moderately decreased, CD4 and CD8 T cell percentage among lymphocytes were similar, and B cell percentage was increased in COVID‐19 patients in comparison to that in HDs. T cells, especially CD8 T cells, showed an enhanced expression of late activation marker CD25 and exhaustion marker PD‐1. Importantly, SARS‐CoV‐2 infection increased the percentage of T follicular helper– and germinal centre B–like cells in the blood. The parameters in COVID‐19 patients remained unchanged across various age groups. Therefore, we demonstrated that the T and B cells are activated naturally and are functional during SARS‐CoV‐2 infection. These data provide evidence that the adaptive immunity in most patients could be primed to induce a significant immune response against SARS‐CoV‐2 infection upon receiving standard medical care. John Wiley and Sons Inc. 2020-09-25 2020-11 /pmc/articles/PMC7537162/ /pubmed/32975374 http://dx.doi.org/10.1111/jcmm.15771 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yang, Xiaofeng
Dai, Tongxin
Zhou, Xiaobo
Qian, Hongbo
Guo, Rui
Lei, Lei
Zhang, Xingzhe
Zhang, Dan
Shi, Lin
Cheng, Yanbin
Hu, Jinsong
Guo, Yaling
Zhang, Baojun
Naturally activated adaptive immunity in COVID‐19 patients
title Naturally activated adaptive immunity in COVID‐19 patients
title_full Naturally activated adaptive immunity in COVID‐19 patients
title_fullStr Naturally activated adaptive immunity in COVID‐19 patients
title_full_unstemmed Naturally activated adaptive immunity in COVID‐19 patients
title_short Naturally activated adaptive immunity in COVID‐19 patients
title_sort naturally activated adaptive immunity in covid‐19 patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537162/
https://www.ncbi.nlm.nih.gov/pubmed/32975374
http://dx.doi.org/10.1111/jcmm.15771
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