Cargando…
ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance t...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537343/ https://www.ncbi.nlm.nih.gov/pubmed/32851409 http://dx.doi.org/10.1085/jgp.202012679 |
_version_ | 1783590656127533056 |
---|---|
author | Melzer, Werner |
author_facet | Melzer, Werner |
author_sort | Melzer, Werner |
collection | PubMed |
description | In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance to force decline resulting from SR Ca(2+) depletion during repetitive muscle activity. |
format | Online Article Text |
id | pubmed-7537343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75373432021-04-05 ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells Melzer, Werner J Gen Physiol Commentary In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance to force decline resulting from SR Ca(2+) depletion during repetitive muscle activity. Rockefeller University Press 2020-08-26 /pmc/articles/PMC7537343/ /pubmed/32851409 http://dx.doi.org/10.1085/jgp.202012679 Text en © 2020 Melzer http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentary Melzer, Werner ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title | ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title_full | ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title_fullStr | ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title_full_unstemmed | ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title_short | ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells |
title_sort | ecc meets ceu—new focus on the backdoor for calcium ions in skeletal muscle cells |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537343/ https://www.ncbi.nlm.nih.gov/pubmed/32851409 http://dx.doi.org/10.1085/jgp.202012679 |
work_keys_str_mv | AT melzerwerner eccmeetsceunewfocusonthebackdoorforcalciumionsinskeletalmusclecells |