ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells

In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance t...

Descripción completa

Detalles Bibliográficos
Autor principal: Melzer, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537343/
https://www.ncbi.nlm.nih.gov/pubmed/32851409
http://dx.doi.org/10.1085/jgp.202012679
_version_ 1783590656127533056
author Melzer, Werner
author_facet Melzer, Werner
author_sort Melzer, Werner
collection PubMed
description In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance to force decline resulting from SR Ca(2+) depletion during repetitive muscle activity.
format Online
Article
Text
id pubmed-7537343
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-75373432021-04-05 ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells Melzer, Werner J Gen Physiol Commentary In this issue, Michelucci et al. report the existence of specific sites acting as Ca(2+) entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca(2+) binding protein of the SR. The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance to force decline resulting from SR Ca(2+) depletion during repetitive muscle activity. Rockefeller University Press 2020-08-26 /pmc/articles/PMC7537343/ /pubmed/32851409 http://dx.doi.org/10.1085/jgp.202012679 Text en © 2020 Melzer http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Melzer, Werner
ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title_full ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title_fullStr ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title_full_unstemmed ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title_short ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells
title_sort ecc meets ceu—new focus on the backdoor for calcium ions in skeletal muscle cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537343/
https://www.ncbi.nlm.nih.gov/pubmed/32851409
http://dx.doi.org/10.1085/jgp.202012679
work_keys_str_mv AT melzerwerner eccmeetsceunewfocusonthebackdoorforcalciumionsinskeletalmusclecells

Ejemplares similares