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Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel

The voltage-gated proton channel (H(V)1) is a voltage sensor that also conducts protons. The singular ability of protons to penetrate proteins complicates distinguishing closed and open channels. When we replaced valine with histidine at position 116 in the external vestibule of hH(V)1, current was...

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Detalles Bibliográficos
Autores principales:	Cherny, Vladimir V., Musset, Boris, Morgan, Deri, Thomas, Sarah, Smith, Susan M.E., DeCoursey, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537347/ https://www.ncbi.nlm.nih.gov/pubmed/32902579 http://dx.doi.org/10.1085/jgp.202012664

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