FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32a(H)) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to...

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Detalles Bibliográficos
Autores principales: Hubbard, Jonathan J., Pyzik, Michal, Rath, Timo, Kozicky, Lisa K., Sand, Kine M.K., Gandhi, Amit K., Grevys, Algirdas, Foss, Stian, Menzies, Susan C., Glickman, Jonathan N., Fiebiger, Edda, Roopenian, Derry C., Sandlie, Inger, Andersen, Jan Terje, Sly, Laura M., Baker, Kristi, Blumberg, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537387/
https://www.ncbi.nlm.nih.gov/pubmed/32658257
http://dx.doi.org/10.1084/jem.20200359

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