A third Notch in colorectal cancer progression and metastasis

In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall survival of the four CMSs. Transcriptomic and bioin...

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Detalles Bibliográficos
Autores principales: Koch, Ute, Radtke, Freddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537388/
https://www.ncbi.nlm.nih.gov/pubmed/32852523
http://dx.doi.org/10.1084/jem.20201017
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author Koch, Ute
Radtke, Freddy
author_facet Koch, Ute
Radtke, Freddy
author_sort Koch, Ute
collection PubMed
description In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall survival of the four CMSs. Transcriptomic and bioinformatic analysis combined with pharmacological and genetic studies identified Notch3 as a promoter of tumor progression and metastasis. NOTCH3 expression was up-regulated in CMS4 CRC patients and associated with tumor staging, lymph node and distant metastasis. These findings feature NOTCH3 as putative therapeutic target for advanced CMS4 CRC patients.
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spelling pubmed-75373882021-04-05 A third Notch in colorectal cancer progression and metastasis Koch, Ute Radtke, Freddy J Exp Med Insights In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall survival of the four CMSs. Transcriptomic and bioinformatic analysis combined with pharmacological and genetic studies identified Notch3 as a promoter of tumor progression and metastasis. NOTCH3 expression was up-regulated in CMS4 CRC patients and associated with tumor staging, lymph node and distant metastasis. These findings feature NOTCH3 as putative therapeutic target for advanced CMS4 CRC patients. Rockefeller University Press 2020-08-26 /pmc/articles/PMC7537388/ /pubmed/32852523 http://dx.doi.org/10.1084/jem.20201017 Text en © 2020 Koch and Radtke http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Koch, Ute
Radtke, Freddy
A third Notch in colorectal cancer progression and metastasis
title A third Notch in colorectal cancer progression and metastasis
title_full A third Notch in colorectal cancer progression and metastasis
title_fullStr A third Notch in colorectal cancer progression and metastasis
title_full_unstemmed A third Notch in colorectal cancer progression and metastasis
title_short A third Notch in colorectal cancer progression and metastasis
title_sort third notch in colorectal cancer progression and metastasis
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537388/
https://www.ncbi.nlm.nih.gov/pubmed/32852523
http://dx.doi.org/10.1084/jem.20201017
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