Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

Cerebral cavernous malformations (CCMs) form following loss of the CCM protein complex in brain endothelial cells due to increased endothelial MEKK3 signaling and KLF2/4 transcription factor expression, but the downstream events that drive lesion formation remain undefined. Recent studies have revea...

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Detalles Bibliográficos
Autores principales: Hong, Courtney C., Tang, Alan T., Detter, Matthew R., Choi, Jaesung P., Wang, Rui, Yang, Xi, Guerrero, Andrea A., Wittig, Carl F., Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Goddard, Lauren M., Ren, Aileen A., Leu, N. Adrian, Sterling, Stephanie, Yang, Jisheng, Li, Li, Chen, Mei, Mericko-Ishizuka, Patricia, Dow, Lukas E., Watanabe, Hideto, Schwaninger, Markus, Min, Wang, Marchuk, Douglas A., Zheng, Xiangjian, Awad, Issam A., Kahn, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537394/
https://www.ncbi.nlm.nih.gov/pubmed/32648916
http://dx.doi.org/10.1084/jem.20200140

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