PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic enzyme required for cancer cell proliferation and tumor progression, is a key factor mediating Th17 cell differentiation and...

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Detalles Bibliográficos
Autores principales: Damasceno, Luis Eduardo Alves, Prado, Douglas Silva, Veras, Flavio Protasio, Fonseca, Miriam M., Toller-Kawahisa, Juliana E., Rosa, Marcos Henrique, Públio, Gabriel Azevedo, Martins, Timna Varela, Ramalho, Fernando S., Waisman, Ari, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Alves-Filho, José Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537396/
https://www.ncbi.nlm.nih.gov/pubmed/32697823
http://dx.doi.org/10.1084/jem.20190613

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