Cargando…

Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study

OBJECTIVES: A lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to metabolic syndrome (MetS). There is a paucity of longitudinal studies to examine whether relative HGS at baseline is linked to incident MetS. Thus, the purpose of the present study was to explore...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Chao, Lu, Jiangting, Xu, Zhijie, Xu, Yuanyuan, Yang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537454/
https://www.ncbi.nlm.nih.gov/pubmed/33020107
http://dx.doi.org/10.1136/bmjopen-2020-041384
_version_ 1783590677169307648
author Shen, Chao
Lu, Jiangting
Xu, Zhijie
Xu, Yuanyuan
Yang, Ying
author_facet Shen, Chao
Lu, Jiangting
Xu, Zhijie
Xu, Yuanyuan
Yang, Ying
author_sort Shen, Chao
collection PubMed
description OBJECTIVES: A lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to metabolic syndrome (MetS). There is a paucity of longitudinal studies to examine whether relative HGS at baseline is linked to incident MetS. Thus, the purpose of the present study was to explore the association between relative HGS and new-onset MetS. DESIGN: This is an observational and longitudinal research. A nationally representative sample of population in China. PARTICIPANTS: A total of 3350 subjects without MetS were selected for analysis in the present study. Data are from the China Health and Retirement Longitudinal Study (2011–2015). OUTCOME MEASURES: We calculated the relative HGS by dividing the HGS by body weight. Participants were divided into gender-specific quartiles. We estimated HRs for MetS and its components using Cox proportional hazard models according to the relative HGS categories. RESULTS: After multiple adjustment, the risk of MetS increased with the lower quartile of relative HGS in both sexes. Using the highest quartile (Q4) as a reference, the HR for quartile Q3–1 was 1.49 (0.95, 2.34), 1.67 (1.08, 2.59) and 1.76 (1.12, 2.78), respectively, in men, and 1.14 (0.82, 1.58), 1.30 (1.02, 1.57) and 1.28 (1.03, 1.55), respectively, in women. Additionally, we observed that relative HGS was negatively or inversely associated with the risk of abdominal obesity in both sexes. CONCLUSIONS: The current study demonstrated that relative HGS was inversely and independently associated with an increased risk of MetS and abdominal obesity, suggesting a possible role of relative HGS as a useful and simple index for muscle strength in the prediction of occurrence of MetS.
format Online
Article
Text
id pubmed-7537454
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-75374542020-10-07 Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study Shen, Chao Lu, Jiangting Xu, Zhijie Xu, Yuanyuan Yang, Ying BMJ Open Epidemiology OBJECTIVES: A lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to metabolic syndrome (MetS). There is a paucity of longitudinal studies to examine whether relative HGS at baseline is linked to incident MetS. Thus, the purpose of the present study was to explore the association between relative HGS and new-onset MetS. DESIGN: This is an observational and longitudinal research. A nationally representative sample of population in China. PARTICIPANTS: A total of 3350 subjects without MetS were selected for analysis in the present study. Data are from the China Health and Retirement Longitudinal Study (2011–2015). OUTCOME MEASURES: We calculated the relative HGS by dividing the HGS by body weight. Participants were divided into gender-specific quartiles. We estimated HRs for MetS and its components using Cox proportional hazard models according to the relative HGS categories. RESULTS: After multiple adjustment, the risk of MetS increased with the lower quartile of relative HGS in both sexes. Using the highest quartile (Q4) as a reference, the HR for quartile Q3–1 was 1.49 (0.95, 2.34), 1.67 (1.08, 2.59) and 1.76 (1.12, 2.78), respectively, in men, and 1.14 (0.82, 1.58), 1.30 (1.02, 1.57) and 1.28 (1.03, 1.55), respectively, in women. Additionally, we observed that relative HGS was negatively or inversely associated with the risk of abdominal obesity in both sexes. CONCLUSIONS: The current study demonstrated that relative HGS was inversely and independently associated with an increased risk of MetS and abdominal obesity, suggesting a possible role of relative HGS as a useful and simple index for muscle strength in the prediction of occurrence of MetS. BMJ Publishing Group 2020-10-05 /pmc/articles/PMC7537454/ /pubmed/33020107 http://dx.doi.org/10.1136/bmjopen-2020-041384 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Shen, Chao
Lu, Jiangting
Xu, Zhijie
Xu, Yuanyuan
Yang, Ying
Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title_full Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title_fullStr Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title_full_unstemmed Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title_short Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
title_sort association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537454/
https://www.ncbi.nlm.nih.gov/pubmed/33020107
http://dx.doi.org/10.1136/bmjopen-2020-041384
work_keys_str_mv AT shenchao associationbetweenhandgripstrengthandtheriskofnewonsetmetabolicsyndromeapopulationbasedcohortstudy
AT lujiangting associationbetweenhandgripstrengthandtheriskofnewonsetmetabolicsyndromeapopulationbasedcohortstudy
AT xuzhijie associationbetweenhandgripstrengthandtheriskofnewonsetmetabolicsyndromeapopulationbasedcohortstudy
AT xuyuanyuan associationbetweenhandgripstrengthandtheriskofnewonsetmetabolicsyndromeapopulationbasedcohortstudy
AT yangying associationbetweenhandgripstrengthandtheriskofnewonsetmetabolicsyndromeapopulationbasedcohortstudy