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Can endolysosomal deacidification and inhibition of autophagy prevent severe COVID-19?

The possibility is examined that immunomodulatory pharmacotherapy may be clinically useful in managing the pandemic coronavirus disease 2019 (COVID-19), known to result from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense single-stranded RNA virus. The...

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Detalles Bibliográficos
Autores principales: Morris, Gerwyn, Athan, Eugene, Walder, Ken, Bortolasci, Chiara C., O'Neil, Adrienne, Marx, Wolf, Berk, Michael, Carvalho, André F., Maes, Michael, Puri, Basant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537668/
https://www.ncbi.nlm.nih.gov/pubmed/33035581
http://dx.doi.org/10.1016/j.lfs.2020.118541