circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network

Osteosarcoma (OS) is a widely common sort among bone cancer in children, and its overall survival ratio is low. The hidden mechanism of tumor genesis, progression, and metastasis regarding osteosarcoma needed to be further investigated. Emerging studies concentrated on exploring the functional roles...

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Detalles Bibliográficos
Autores principales: Zhang, Hepeng, Meng, Fanyu, Dong, Shuaicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537690/
https://www.ncbi.nlm.nih.gov/pubmed/33029498
http://dx.doi.org/10.1155/2020/2539150
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author Zhang, Hepeng
Meng, Fanyu
Dong, Shuaicheng
author_facet Zhang, Hepeng
Meng, Fanyu
Dong, Shuaicheng
author_sort Zhang, Hepeng
collection PubMed
description Osteosarcoma (OS) is a widely common sort among bone cancer in children, and its overall survival ratio is low. The hidden mechanism of tumor genesis, progression, and metastasis regarding osteosarcoma needed to be further investigated. Emerging studies concentrated on exploring the functional roles of circular RNAs (circRNAs) in human cancers. The present study conducted a loss-of-function experiments to explore the circSMARCA5-induced influence on OS proliferation, cell cycle, and metastasis. Moreover, our manuscript unearthed the potential mechanisms of circSMARCA5 in regulating OS progression by in silico analysis. Our findings would provide new evidence to support that circSMARCA5 could be indicated as a biomarker for OS.
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spelling pubmed-75376902020-10-06 circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network Zhang, Hepeng Meng, Fanyu Dong, Shuaicheng Biomed Res Int Research Article Osteosarcoma (OS) is a widely common sort among bone cancer in children, and its overall survival ratio is low. The hidden mechanism of tumor genesis, progression, and metastasis regarding osteosarcoma needed to be further investigated. Emerging studies concentrated on exploring the functional roles of circular RNAs (circRNAs) in human cancers. The present study conducted a loss-of-function experiments to explore the circSMARCA5-induced influence on OS proliferation, cell cycle, and metastasis. Moreover, our manuscript unearthed the potential mechanisms of circSMARCA5 in regulating OS progression by in silico analysis. Our findings would provide new evidence to support that circSMARCA5 could be indicated as a biomarker for OS. Hindawi 2020-09-27 /pmc/articles/PMC7537690/ /pubmed/33029498 http://dx.doi.org/10.1155/2020/2539150 Text en Copyright © 2020 Hepeng Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Hepeng
Meng, Fanyu
Dong, Shuaicheng
circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title_full circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title_fullStr circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title_full_unstemmed circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title_short circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network
title_sort circsmarca5 promoted osteosarcoma cell proliferation, adhesion, migration, and invasion through a competing endogenous rna network
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537690/
https://www.ncbi.nlm.nih.gov/pubmed/33029498
http://dx.doi.org/10.1155/2020/2539150
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