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A novel petasin-modified zinc oxide eugenol sealer
OBJECTIVE: Zinc oxide eugenol (ZOE) is one of the most commonly used root canal sealer. However, it has few drawbacks such as cytotoxicity, solubility, and irritation to periapical tissues. The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537762/ https://www.ncbi.nlm.nih.gov/pubmed/33082668 http://dx.doi.org/10.4103/JCD.JCD_475_19 |
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author | Vinola, Selvanathan M. J. Karthikeyan, Kittappa Mahalaxmi, Sekar |
author_facet | Vinola, Selvanathan M. J. Karthikeyan, Kittappa Mahalaxmi, Sekar |
author_sort | Vinola, Selvanathan M. J. |
collection | PubMed |
description | OBJECTIVE: Zinc oxide eugenol (ZOE) is one of the most commonly used root canal sealer. However, it has few drawbacks such as cytotoxicity, solubility, and irritation to periapical tissues. The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with the modification of its liquid component by the addition of petasin extract in the ratios 1:1, 5:1, and 10:1. MATERIALS AND METHODS: Setting time was evaluated using the Vicat's apparatus. For testing solubility, the American Dental Association's specification #8 was adopted with certain modifications. Protein denaturation assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay with L929 mouse fibroblast cell lines were used to evaluate the anti-inflammatory property and cytotoxicity, respectively. RESULTS: ZOE sealer with petasin extract in the ratio of 5:1 showed the least initial and the final setting times. There was no statistically significant difference in the amount of solubility for all the groups at the various time intervals. The cytotoxicity of the control group was significantly greater than all the experimental groups, whereas the anti-inflammatory effect of the former was statistically lower. CONCLUSIONS: The combination of ZOE with petasin extract in the ratio of 5:1 showed lower setting time, cytotoxicity, and better anti-inflammatory property. |
format | Online Article Text |
id | pubmed-7537762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-75377622020-10-19 A novel petasin-modified zinc oxide eugenol sealer Vinola, Selvanathan M. J. Karthikeyan, Kittappa Mahalaxmi, Sekar J Conserv Dent Original Article OBJECTIVE: Zinc oxide eugenol (ZOE) is one of the most commonly used root canal sealer. However, it has few drawbacks such as cytotoxicity, solubility, and irritation to periapical tissues. The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with the modification of its liquid component by the addition of petasin extract in the ratios 1:1, 5:1, and 10:1. MATERIALS AND METHODS: Setting time was evaluated using the Vicat's apparatus. For testing solubility, the American Dental Association's specification #8 was adopted with certain modifications. Protein denaturation assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay with L929 mouse fibroblast cell lines were used to evaluate the anti-inflammatory property and cytotoxicity, respectively. RESULTS: ZOE sealer with petasin extract in the ratio of 5:1 showed the least initial and the final setting times. There was no statistically significant difference in the amount of solubility for all the groups at the various time intervals. The cytotoxicity of the control group was significantly greater than all the experimental groups, whereas the anti-inflammatory effect of the former was statistically lower. CONCLUSIONS: The combination of ZOE with petasin extract in the ratio of 5:1 showed lower setting time, cytotoxicity, and better anti-inflammatory property. Wolters Kluwer - Medknow 2019 2020-08-04 /pmc/articles/PMC7537762/ /pubmed/33082668 http://dx.doi.org/10.4103/JCD.JCD_475_19 Text en Copyright: © 2020 Journal of Conservative Dentistry http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Vinola, Selvanathan M. J. Karthikeyan, Kittappa Mahalaxmi, Sekar A novel petasin-modified zinc oxide eugenol sealer |
title | A novel petasin-modified zinc oxide eugenol sealer |
title_full | A novel petasin-modified zinc oxide eugenol sealer |
title_fullStr | A novel petasin-modified zinc oxide eugenol sealer |
title_full_unstemmed | A novel petasin-modified zinc oxide eugenol sealer |
title_short | A novel petasin-modified zinc oxide eugenol sealer |
title_sort | novel petasin-modified zinc oxide eugenol sealer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537762/ https://www.ncbi.nlm.nih.gov/pubmed/33082668 http://dx.doi.org/10.4103/JCD.JCD_475_19 |
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