Coexisting Somatostatin Receptor Expressing Gastric Neuroendocrine Tumor Primary and Lymph Nodal Tuberculosis on (68)Ga-DOTANOC Positron Emission Tomography/Computed Tomography

Gastric neuroendocrine tumors (G-NETs) express somatostatin receptors (SSTR), which can be imaged using radiolabeled somatostatin analogs, including (68)Ga-DOTA octreotide analogs. SSTR expression is also seen in activated lymphocytes and macrophages, which might result in false-positive results on...

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Detalles Bibliográficos
Autores principales: Arora, Saurabh, Rastogi, Sameer, Shamim, Shamim Ahmed, Barward, Adarsh Wamanrao, Passah, Benjamin Leroy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537921/
https://www.ncbi.nlm.nih.gov/pubmed/33082684
http://dx.doi.org/10.4103/ijnm.IJNM_33_20
Descripción
Sumario:Gastric neuroendocrine tumors (G-NETs) express somatostatin receptors (SSTR), which can be imaged using radiolabeled somatostatin analogs, including (68)Ga-DOTA octreotide analogs. SSTR expression is also seen in activated lymphocytes and macrophages, which might result in false-positive results on SSTR imaging, in patients with coexistent granulomatous pathologies including tuberculosis, sarcoidosis, and Wegener's granulomatosis. We present a case where (68)Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) showed primary G-NET, with SSTR expressing nonregional lymph nodes which on histopathology showed necrotizing granulomas with Langhans histiocytes. Antitubercular therapy was started, and a decrease in size and SSTR expression in involved lymph nodes was noted on follow-up (68)Ga-DOTANOC PET/CT.

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