Cargando…

Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling

Detalles Bibliográficos
Autores principales:	Wu, Yaoxing, Ma, Ling, Zhuang, Zhen, Cai, Sihui, Zhao, Zhiyao, Zhou, Lingli, Zhang, Jing, Wang, Pei-Hui, Zhao, Jincun, Cui, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537955/ https://www.ncbi.nlm.nih.gov/pubmed/33024073 http://dx.doi.org/10.1038/s41392-020-00332-2

Ejemplares similares

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation
por: Wu, Yaoxing, et al.
Publicado: (2021)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
por: Milligan, Jennifer C., et al.
Publicado: (2021)

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy
por: Jin, Shouheng, et al.
Publicado: (2022)

Targeting Ribonucleases with Small Molecules and Bifunctional Molecules
por: Borgelt, Lydia, et al.
Publicado: (2023)

Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
por: Johansen-Leete, Jason, et al.
Publicado: (2022)

Molecular modeling and simulations of some antiviral drugs, benzylisoquinoline alkaloid, and coumarin molecules to investigate the effects on Mpro main viral protease inhibition
por: Mir, Showkat Ahmad, et al.
Publicado: (2023)

HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins
por: Falkenhagen, Alexander, et al.
Publicado: (2018)

Repurposing metocurine as main protease inhibitor to develop novel antiviral therapy for COVID-19
por: Jain, Rashi, et al.
Publicado: (2020)

The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals
por: Wang, Fenghua, et al.
Publicado: (2022)

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
por: Dai, Wenhao, et al.
Publicado: (2020)

Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach
por: Rangsinth, Panthakarn, et al.
Publicado: (2021)

Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex
por: Cai, Sihui, et al.
Publicado: (2023)

The regulation of antiviral activity of interferon epsilon
por: Zhao, Fu-Rong, et al.
Publicado: (2022)

Norovirus Protease Structure and Antivirals Development
por: Zhao, Boyang, et al.
Publicado: (2021)

Search of Novel Small Molecule Inhibitors for the Main Protease of SARS-CoV-2
por: Zhang, Wenfa, et al.
Publicado: (2023)

Probing CAS database as prospective antiviral agents against SARS-CoV-2 main protease
por: Zia, Komal, et al.
Publicado: (2021)

Antiviral drug discovery by targeting the SARS-CoV-2 polyprotein processing by inhibition of the main protease
por: Kandeel, Mahmoud, et al.
Publicado: (2022)

Prospective Role of Peptide-Based Antiviral Therapy Against the Main Protease of SARS-CoV-2
por: Mahmud, Shafi, et al.
Publicado: (2021)

Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency
por: Zhang, Chun-Hui, et al.
Publicado: (2021)

A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals
por: Alugubelli, Yugendar R., et al.
Publicado: (2022)

In silico and in vitro evaluation of antiviral activity of wogonin against main protease of porcine epidemic diarrhea virus
por: Wang, Jieru, et al.
Publicado: (2023)

SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense
por: Ju, Xiaohui, et al.
Publicado: (2023)

Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
por: Liang, Meihao, et al.
Publicado: (2022)

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
por: Wu, Yaoxing, et al.
Publicado: (2017)

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
por: Wu, Yaoxing, et al.
Publicado: (2017)

Antiviral activities of interferons
por: Stewart, William E., et al.
Publicado: (1979)

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus
por: Ren, Ying, et al.
Publicado: (2016)

A bifunctional molecule-based strategy for the development of theranostic antibody-drug conjugate
por: Xiao, Dian, et al.
Publicado: (2021)

In silico screening of antiviral compounds from Moringa oleifera for inhibition of SARS-CoV-2 main protease
por: Sivani, Bala Mohan, et al.
Publicado: (2021)

Antiviral peptides against the main protease of SARS-CoV-2: A molecular docking and dynamics study
por: Mahmud, Shafi, et al.
Publicado: (2021)

In Silico Discovery of Small-Molecule Inhibitors Targeting SARS-CoV-2 Main Protease
por: Gao, Menghan, et al.
Publicado: (2023)

Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
por: Huang, Jingxi, et al.
Publicado: (2023)

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs
por: Li, Zhe, et al.
Publicado: (2020)

Molecular modeling evaluation of the binding effect of five protease inhibitors to COVID-19 main protease
por: Liu, Jian, et al.
Publicado: (2021)

Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Sonochemical Reaction of Bifunctional Molecules on Silicon (111) Hydride Surface
por: Zida, Serge Ismael, et al.
Publicado: (2021)

Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
por: Liu, Qingxiang, et al.
Publicado: (2018)

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
por: Zhao, Yao, et al.
Publicado: (2021)

Molecular mechanisms and cellular functions of liquid-liquid phase separation during antiviral immune responses
por: Yang, Shuai, et al.
Publicado: (2023)

In silico evidence of antiviral activity against SARS-CoV-2 main protease of oligosaccharides from Porphyridium sp.
por: Ben Hlima, Hajer, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ib52tu3b4d4aoimqf31l7vo69p