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Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine

Fluorine-19 ((19)F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the (19)F atom in vivo. Perfluorocarbons (PFCs) have been used as blood sub...

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Detalles Bibliográficos
Autores principales: Wu, Lina, Liu, Fang, Liu, Shuang, Xu, Xiuan, Liu, Zhaoxi, Sun, Xilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537992/
https://www.ncbi.nlm.nih.gov/pubmed/33061385
http://dx.doi.org/10.2147/IJN.S255084
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author Wu, Lina
Liu, Fang
Liu, Shuang
Xu, Xiuan
Liu, Zhaoxi
Sun, Xilin
author_facet Wu, Lina
Liu, Fang
Liu, Shuang
Xu, Xiuan
Liu, Zhaoxi
Sun, Xilin
author_sort Wu, Lina
collection PubMed
description Fluorine-19 ((19)F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the (19)F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of (19)F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative (19)F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.
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spelling pubmed-75379922020-10-14 Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine Wu, Lina Liu, Fang Liu, Shuang Xu, Xiuan Liu, Zhaoxi Sun, Xilin Int J Nanomedicine Review Fluorine-19 ((19)F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the (19)F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of (19)F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative (19)F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al. Dove 2020-10-02 /pmc/articles/PMC7537992/ /pubmed/33061385 http://dx.doi.org/10.2147/IJN.S255084 Text en © 2020 Wu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wu, Lina
Liu, Fang
Liu, Shuang
Xu, Xiuan
Liu, Zhaoxi
Sun, Xilin
Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title_full Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title_fullStr Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title_full_unstemmed Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title_short Perfluorocarbons-Based (19)F Magnetic Resonance Imaging in Biomedicine
title_sort perfluorocarbons-based (19)f magnetic resonance imaging in biomedicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537992/
https://www.ncbi.nlm.nih.gov/pubmed/33061385
http://dx.doi.org/10.2147/IJN.S255084
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