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A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19

BACKGROUND: The COVID-19 pandemic hit all over the world, and cancer patients are more vulnerable for COVID-19. The mortality rate may increase up to 25% in solid malignancies. In parallel to increased mortality rates among cancer patients, safety concerns regarding cancer treatment has increased ov...

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Autores principales: Yekedüz, Emre, Utkan, Güngör, Ürün, Yüksel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538140/
https://www.ncbi.nlm.nih.gov/pubmed/33130550
http://dx.doi.org/10.1016/j.ejca.2020.09.028
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author Yekedüz, Emre
Utkan, Güngör
Ürün, Yüksel
author_facet Yekedüz, Emre
Utkan, Güngör
Ürün, Yüksel
author_sort Yekedüz, Emre
collection PubMed
description BACKGROUND: The COVID-19 pandemic hit all over the world, and cancer patients are more vulnerable for COVID-19. The mortality rate may increase up to 25% in solid malignancies. In parallel to increased mortality rates among cancer patients, safety concerns regarding cancer treatment has increased over time. However, there were contradictory results for the cancer treatment during pandemic. In this study, we assessed the effect of cancer treatment on the severity of COVID-19. METHODS: The MEDLINE database was searched on September 01, 2020. Primary end-points were severe disease and death in the cancer patients treated within the last 30 days before COVID-19 diagnosis. Quality of included studies was assessed by Newcastle–Ottawa scale. The generic inverse-variance method was used to calculate odds ratios (ORs) for each outcome. RESULTS: Sixteen studies were included for this meta-analysis. Chemotherapy within the last thirty days before COVID-19 diagnosis increased the risk of death in cancer patients after adjusting for confounding variables (OR: 1.85; 95% confidence interval: 1.26–2.71). However, severe COVID-19 risk did not increase. Furthermore, targeted therapies, immunotherapy, surgery and radiotherapy did not increase the severe disease and death risk in cancer patients with COVID-19. CONCLUSION: Chemotherapy increased the risk of death from COVID-19 in cancer patients. However, there was no safety concern for immunotherapy, targeted therapies, surgery and radiotherapy.
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spelling pubmed-75381402020-10-07 A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19 Yekedüz, Emre Utkan, Güngör Ürün, Yüksel Eur J Cancer Review BACKGROUND: The COVID-19 pandemic hit all over the world, and cancer patients are more vulnerable for COVID-19. The mortality rate may increase up to 25% in solid malignancies. In parallel to increased mortality rates among cancer patients, safety concerns regarding cancer treatment has increased over time. However, there were contradictory results for the cancer treatment during pandemic. In this study, we assessed the effect of cancer treatment on the severity of COVID-19. METHODS: The MEDLINE database was searched on September 01, 2020. Primary end-points were severe disease and death in the cancer patients treated within the last 30 days before COVID-19 diagnosis. Quality of included studies was assessed by Newcastle–Ottawa scale. The generic inverse-variance method was used to calculate odds ratios (ORs) for each outcome. RESULTS: Sixteen studies were included for this meta-analysis. Chemotherapy within the last thirty days before COVID-19 diagnosis increased the risk of death in cancer patients after adjusting for confounding variables (OR: 1.85; 95% confidence interval: 1.26–2.71). However, severe COVID-19 risk did not increase. Furthermore, targeted therapies, immunotherapy, surgery and radiotherapy did not increase the severe disease and death risk in cancer patients with COVID-19. CONCLUSION: Chemotherapy increased the risk of death from COVID-19 in cancer patients. However, there was no safety concern for immunotherapy, targeted therapies, surgery and radiotherapy. Elsevier Ltd. 2020-12 2020-10-06 /pmc/articles/PMC7538140/ /pubmed/33130550 http://dx.doi.org/10.1016/j.ejca.2020.09.028 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Yekedüz, Emre
Utkan, Güngör
Ürün, Yüksel
A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title_full A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title_fullStr A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title_full_unstemmed A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title_short A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
title_sort systematic review and meta-analysis: the effect of active cancer treatment on severity of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538140/
https://www.ncbi.nlm.nih.gov/pubmed/33130550
http://dx.doi.org/10.1016/j.ejca.2020.09.028
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